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Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network

Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network
Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network
Osteocytes are the most abundant cells in bone and the only cells embedded in the bone mineral matrix. They form an extended, three-dimensional (3D) network, whose processes interconnecting the cell bodies reside in thin canals, the canaliculi. Together with the osteocyte lacunae, the canaliculi form the lacuno-canalicular network (LCN). As the negative imprint of the cellular network within bone tissue, the LCN morphology is considered to play a central role for bone mechanosensation and mechanotransduction. However, the LCN has neither been visualized nor quantified in an adequate way up to now. On this account, this article summarizes the current state of knowledge of the LCN morphology and then reviews different imaging methods regarding the quantitative 3D assessment of bone tissue in general and of the LCN in particular. These imaging methods will provide new insights in the field of bone mechanosensation and mechanotransduction and thus, into processes of strain sensation and transduction, which are tightly associated with osteocyte viability and bone quality.
8756-3282
848-858
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Meier, Matias
afbffe86-2d00-43c7-aa28-844c74153a59
Wepf, Roger
990f9d94-58da-41a5-8059-4d08a3ae0784
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Meier, Matias
afbffe86-2d00-43c7-aa28-844c74153a59
Wepf, Roger
990f9d94-58da-41a5-8059-4d08a3ae0784
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036

Schneider, Philipp, Meier, Matias, Wepf, Roger and Müller, Ralph (2010) Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network. Bone, 47 (5), 848-858. (doi:10.1016/j.bone.2010.07.026).

Record type: Article

Abstract

Osteocytes are the most abundant cells in bone and the only cells embedded in the bone mineral matrix. They form an extended, three-dimensional (3D) network, whose processes interconnecting the cell bodies reside in thin canals, the canaliculi. Together with the osteocyte lacunae, the canaliculi form the lacuno-canalicular network (LCN). As the negative imprint of the cellular network within bone tissue, the LCN morphology is considered to play a central role for bone mechanosensation and mechanotransduction. However, the LCN has neither been visualized nor quantified in an adequate way up to now. On this account, this article summarizes the current state of knowledge of the LCN morphology and then reviews different imaging methods regarding the quantitative 3D assessment of bone tissue in general and of the LCN in particular. These imaging methods will provide new insights in the field of bone mechanosensation and mechanotransduction and thus, into processes of strain sensation and transduction, which are tightly associated with osteocyte viability and bone quality.

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More information

e-pub ahead of print date: 3 August 2010
Published date: November 2010
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 361069
URI: http://eprints.soton.ac.uk/id/eprint/361069
ISSN: 8756-3282
PURE UUID: 95fea8e2-7ff3-4e3d-91df-2d6849ea9278
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

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Date deposited: 14 Jan 2014 16:38
Last modified: 26 Nov 2019 01:34

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Contributors

Author: Matias Meier
Author: Roger Wepf
Author: Ralph Müller

University divisions

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