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Analysis of sintered polymer scaffolds using concomitant synchrotron computed tomography and in situ mechanical testing

Analysis of sintered polymer scaffolds using concomitant synchrotron computed tomography and in situ mechanical testing
Analysis of sintered polymer scaffolds using concomitant synchrotron computed tomography and in situ mechanical testing
The mechanical behaviour of polymer scaffolds plays a vital role in their successful use in bone tissue engineering. The present study utilised novel sintered polymer scaffolds prepared using temperature-sensitive poly(DL-lactic acid-co-glycolic acid)/poly(ethylene glycol) particles. The microstructure of these scaffolds was monitored under compressive strain by image-guided failure assessment (IGFA), which combined synchrotron radiation computed tomography (SR CT) and in situ micro-compression. Three-dimensional CT data sets of scaffolds subjected to a strain rate of 0.01%/s illustrated particle movement within the scaffolds with no deformation or cracking. When compressed using a higher strain rate of 0.02%/s particle movement was more pronounced and cracks between sintered particles were observed. The results from this study demonstrate that IGFA based on simultaneous SR CT imaging and micro-compression testing is a useful tool for assessing structural and mechanical scaffold properties, leading to further insight into structure–function relationships in scaffolds for bone tissue engineering applications.
0957-4530
2599-2605
Dhillon, Amritpaul
eca34484-432d-4e71-92d1-ce7267be8303
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Kuhn, Gisela
8bd3e76b-e879-4117-9010-6d9cbcf6989f
Reinwald, Yvonne
968516a1-4b39-4183-a99a-32ae33460fdf
White, Lincoln J.
cf6f30d7-b653-422c-8825-894b53bfc103
Levchuk, Alina
252a6376-fd80-49d7-a6ac-f2368c00d62b
Rose, Felicity R.A.J.
ffeec12e-9182-4466-a719-0627b236cd22
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Shakesheff, Kevin M.
5b9ed879-e2c5-4c62-bb38-abd2bb4960ac
Rahman, Cheryl V.
22891737-7368-459c-aa66-c008881d2844
Dhillon, Amritpaul
eca34484-432d-4e71-92d1-ce7267be8303
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Kuhn, Gisela
8bd3e76b-e879-4117-9010-6d9cbcf6989f
Reinwald, Yvonne
968516a1-4b39-4183-a99a-32ae33460fdf
White, Lincoln J.
cf6f30d7-b653-422c-8825-894b53bfc103
Levchuk, Alina
252a6376-fd80-49d7-a6ac-f2368c00d62b
Rose, Felicity R.A.J.
ffeec12e-9182-4466-a719-0627b236cd22
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Shakesheff, Kevin M.
5b9ed879-e2c5-4c62-bb38-abd2bb4960ac
Rahman, Cheryl V.
22891737-7368-459c-aa66-c008881d2844

Dhillon, Amritpaul, Schneider, Philipp, Kuhn, Gisela, Reinwald, Yvonne, White, Lincoln J., Levchuk, Alina, Rose, Felicity R.A.J., Müller, Ralph, Shakesheff, Kevin M. and Rahman, Cheryl V. (2011) Analysis of sintered polymer scaffolds using concomitant synchrotron computed tomography and in situ mechanical testing. Journal of Materials Science: Materials in Medicine, 22 (12), 2599-2605. (doi:10.1007/s10856-011-4443-z).

Record type: Article

Abstract

The mechanical behaviour of polymer scaffolds plays a vital role in their successful use in bone tissue engineering. The present study utilised novel sintered polymer scaffolds prepared using temperature-sensitive poly(DL-lactic acid-co-glycolic acid)/poly(ethylene glycol) particles. The microstructure of these scaffolds was monitored under compressive strain by image-guided failure assessment (IGFA), which combined synchrotron radiation computed tomography (SR CT) and in situ micro-compression. Three-dimensional CT data sets of scaffolds subjected to a strain rate of 0.01%/s illustrated particle movement within the scaffolds with no deformation or cracking. When compressed using a higher strain rate of 0.02%/s particle movement was more pronounced and cracks between sintered particles were observed. The results from this study demonstrate that IGFA based on simultaneous SR CT imaging and micro-compression testing is a useful tool for assessing structural and mechanical scaffold properties, leading to further insight into structure–function relationships in scaffolds for bone tissue engineering applications.

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More information

e-pub ahead of print date: 10 September 2011
Published date: December 2011
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 361071
URI: http://eprints.soton.ac.uk/id/eprint/361071
ISSN: 0957-4530
PURE UUID: 9e073c68-9fbf-43b2-a2a1-34d1cc1dbbab
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

Catalogue record

Date deposited: 14 Jan 2014 16:41
Last modified: 20 Jul 2019 00:37

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Contributors

Author: Amritpaul Dhillon
Author: Gisela Kuhn
Author: Yvonne Reinwald
Author: Lincoln J. White
Author: Alina Levchuk
Author: Felicity R.A.J. Rose
Author: Ralph Müller
Author: Kevin M. Shakesheff
Author: Cheryl V. Rahman

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