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The importance of murine cortical bone microstructure for microcrack initiation and propagation

The importance of murine cortical bone microstructure for microcrack initiation and propagation
The importance of murine cortical bone microstructure for microcrack initiation and propagation
In order to better understand bone postyield behavior and consequently bone failure behavior, this study aimed first to investigate cortical bone microstructure and second, to relate cortical bone microstructure to microdamage initiation and propagation in C57BL/6 (B6) and C3H/He (C3H) mice; two murine inbred strains known for their differences in bone phenotype. Murine femora of B6 and C3H were loaded axially under compression in a stepwise manner. For each loading step, 3D data sets at a nominal resolution of 700 nm were acquired by means of synchrotron radiation-based computed tomography. Cortical bone microstructure was divided into three phases: the canal network, the osteocyte lacunar system, and microdamage. Canal volume density and canal unit volume both correlated highly to crack number density (canal volume density: R2=0.64, p<0.005 and canal unit volume: R2=0.75, p<0.001). Moreover, the large canal units in C3H bone were responsible for more microdamage accumulation compared to B6 bones. This more pronounced microdamage accumulation due to large intracortical bone voids, which eventually leads to a fatal macrocrack (fracture), represents a potential contributing factor to the higher incidence of bone fractures in the elderly.
8756-3282
1186-1193
Voide, Romain
8859d4cc-c065-4034-b350-0538997ce8fe
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Stauber, Martin
f69dbdc0-ebca-41eb-aab7-0679e6b78874
van Lenthe, Gerrit H.
17879e8c-2f55-4317-a0f1-fbde09e72e6e
Stampanoni, Marco
bfedb3b0-01e8-4e1b-9163-41295b4ceeb1
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Voide, Romain
8859d4cc-c065-4034-b350-0538997ce8fe
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Stauber, Martin
f69dbdc0-ebca-41eb-aab7-0679e6b78874
van Lenthe, Gerrit H.
17879e8c-2f55-4317-a0f1-fbde09e72e6e
Stampanoni, Marco
bfedb3b0-01e8-4e1b-9163-41295b4ceeb1
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036

Voide, Romain, Schneider, Philipp, Stauber, Martin, van Lenthe, Gerrit H., Stampanoni, Marco and Müller, Ralph (2011) The importance of murine cortical bone microstructure for microcrack initiation and propagation. Bone, 49 (6), 1186-1193. (doi:10.1016/j.bone.2011.08.011). (PMID:21884836)

Record type: Article

Abstract

In order to better understand bone postyield behavior and consequently bone failure behavior, this study aimed first to investigate cortical bone microstructure and second, to relate cortical bone microstructure to microdamage initiation and propagation in C57BL/6 (B6) and C3H/He (C3H) mice; two murine inbred strains known for their differences in bone phenotype. Murine femora of B6 and C3H were loaded axially under compression in a stepwise manner. For each loading step, 3D data sets at a nominal resolution of 700 nm were acquired by means of synchrotron radiation-based computed tomography. Cortical bone microstructure was divided into three phases: the canal network, the osteocyte lacunar system, and microdamage. Canal volume density and canal unit volume both correlated highly to crack number density (canal volume density: R2=0.64, p<0.005 and canal unit volume: R2=0.75, p<0.001). Moreover, the large canal units in C3H bone were responsible for more microdamage accumulation compared to B6 bones. This more pronounced microdamage accumulation due to large intracortical bone voids, which eventually leads to a fatal macrocrack (fracture), represents a potential contributing factor to the higher incidence of bone fractures in the elderly.

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Published date: 22 August 2011
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 361072
URI: http://eprints.soton.ac.uk/id/eprint/361072
ISSN: 8756-3282
PURE UUID: 18736dc2-52f2-46cb-9c4d-a2041349076b
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

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Date deposited: 13 Jan 2014 12:09
Last modified: 17 Dec 2019 01:36

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Contributors

Author: Romain Voide
Author: Martin Stauber
Author: Gerrit H. van Lenthe
Author: Marco Stampanoni
Author: Ralph Müller

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