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Deformable image registration and 3D strain mapping for the quantitative assessment of cortical bone microdamage

Deformable image registration and 3D strain mapping for the quantitative assessment of cortical bone microdamage
Deformable image registration and 3D strain mapping for the quantitative assessment of cortical bone microdamage
The resistance to forming microcracks is a key factor for bone to withstand critical loads without fracturing. In this study, we investigated the initiation and propagation of microcracks in murine cortical bone by combining three-dimensional images from synchrotron radiation-based computed tomography and time-lapsed biomechanical testing to observe microdamage accumulation over time. Furthermore, a novel deformable image registration procedure utilizing digital volume correlation and demons image registration was introduced to compute 3D strain maps allowing characterization of the mechanical environment of the microcracks. The displacement and strain maps were validated in a priori tests. At an image resolution of 740 nm the spatial resolution of the strain maps was 10 ?m (MTF), while the errors of the displacements and strains were 130 nm and 0.013, respectively. The strain maps revealed a complex interaction of the propagating microcracks with the bone microstructure. In particular, we could show that osteocyte lacunae play a dual role as stress concentrating features reducing bone strength, while at the same time contributing to the bone toughness by blunting the crack tip. We conclude that time-lapsed biomechanical imaging in combination with three-dimensional strain mapping is suitable for the investigation of crack initiation and propagation in many porous materials under various loading scenarios.
1751-6161
184-193
Christen, David
0b33debf-b393-40a9-8699-87b9b7b1a117
Levchuk, Alina
252a6376-fd80-49d7-a6ac-f2368c00d62b
Schori, Stefan
c223af27-723a-4e2e-bf77-65905092d94f
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Boyd, Steven K.
4fb3705e-e7cd-4335-9371-93dd9c535882
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036
Christen, David
0b33debf-b393-40a9-8699-87b9b7b1a117
Levchuk, Alina
252a6376-fd80-49d7-a6ac-f2368c00d62b
Schori, Stefan
c223af27-723a-4e2e-bf77-65905092d94f
Schneider, Philipp
a810f925-4808-44e4-8a4a-a51586f9d7ad
Boyd, Steven K.
4fb3705e-e7cd-4335-9371-93dd9c535882
Müller, Ralph
f881853a-540f-48f1-bb6d-e0cf1894e036

Christen, David, Levchuk, Alina, Schori, Stefan, Schneider, Philipp, Boyd, Steven K. and Müller, Ralph (2012) Deformable image registration and 3D strain mapping for the quantitative assessment of cortical bone microdamage. Journal of the Mechanical Behavior of Biomedical Materials, 8, 184-193. (doi:10.1016/j.jmbbm.2011.12.009). (PMID:22402165)

Record type: Article

Abstract

The resistance to forming microcracks is a key factor for bone to withstand critical loads without fracturing. In this study, we investigated the initiation and propagation of microcracks in murine cortical bone by combining three-dimensional images from synchrotron radiation-based computed tomography and time-lapsed biomechanical testing to observe microdamage accumulation over time. Furthermore, a novel deformable image registration procedure utilizing digital volume correlation and demons image registration was introduced to compute 3D strain maps allowing characterization of the mechanical environment of the microcracks. The displacement and strain maps were validated in a priori tests. At an image resolution of 740 nm the spatial resolution of the strain maps was 10 ?m (MTF), while the errors of the displacements and strains were 130 nm and 0.013, respectively. The strain maps revealed a complex interaction of the propagating microcracks with the bone microstructure. In particular, we could show that osteocyte lacunae play a dual role as stress concentrating features reducing bone strength, while at the same time contributing to the bone toughness by blunting the crack tip. We conclude that time-lapsed biomechanical imaging in combination with three-dimensional strain mapping is suitable for the investigation of crack initiation and propagation in many porous materials under various loading scenarios.

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Published date: 8 January 2012
Organisations: Faculty of Engineering and the Environment

Identifiers

Local EPrints ID: 361073
URI: https://eprints.soton.ac.uk/id/eprint/361073
ISSN: 1751-6161
PURE UUID: 695a9bb3-9a28-4614-838d-90da2b7707a6
ORCID for Philipp Schneider: ORCID iD orcid.org/0000-0001-7499-3576

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Date deposited: 13 Jan 2014 12:56
Last modified: 05 Nov 2019 01:36

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Contributors

Author: David Christen
Author: Alina Levchuk
Author: Stefan Schori
Author: Steven K. Boyd
Author: Ralph Müller

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