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Construction of DNA–polymer hybrids using intercalation interactions

Construction of DNA–polymer hybrids using intercalation interactions
Construction of DNA–polymer hybrids using intercalation interactions
Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy
1359-7345
1338-1340
Wilks, Thomas R.
f3e9f3ae-6f93-4a1b-89a0-6916e353aa24
Pitto-Barry, Anaïs
5ee2b8c8-34ec-4ac4-bceb-9ccc29063344
Kirby, Nigel
f096d265-c00e-42e0-8cd8-fb5ab470f513
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
O'Reilly, Rachel K.
086bc91e-2303-4543-b79c-ae16ada0b101
Wilks, Thomas R.
f3e9f3ae-6f93-4a1b-89a0-6916e353aa24
Pitto-Barry, Anaïs
5ee2b8c8-34ec-4ac4-bceb-9ccc29063344
Kirby, Nigel
f096d265-c00e-42e0-8cd8-fb5ab470f513
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
O'Reilly, Rachel K.
086bc91e-2303-4543-b79c-ae16ada0b101

Wilks, Thomas R., Pitto-Barry, Anaïs, Kirby, Nigel, Stulz, Eugen and O'Reilly, Rachel K. (2014) Construction of DNA–polymer hybrids using intercalation interactions. Chemical Communications, 50, 1338-1340. (doi:10.1039/C3CC48726A).

Record type: Article

Abstract

Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy

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Published date: 2014
Organisations: Chemistry

Identifiers

Local EPrints ID: 361088
URI: http://eprints.soton.ac.uk/id/eprint/361088
ISSN: 1359-7345
PURE UUID: 1b9a91a2-6ab5-4466-bea0-38565aa505c4
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

Catalogue record

Date deposited: 13 Jan 2014 13:25
Last modified: 20 Jul 2019 00:54

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Contributors

Author: Thomas R. Wilks
Author: Anaïs Pitto-Barry
Author: Nigel Kirby
Author: Eugen Stulz ORCID iD
Author: Rachel K. O'Reilly

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