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Nanoparticle-enhanced chemiluminescence in micro-flow injection analysis

Record type: Conference or Workshop Item (Paper)

Chemiluminescence (CL) detection for biomedical analysis has the principal advantage that no optical source is required so that instrumentation is simple and background radiation is minimised, resulting in high sensitivity. CL has been exploited in a wide range of chemical and biochemical measurements such as enzyme-linked immunoassays (ELISA), DNA sequencing, and for the analysis of biomedical, food and environmental samples [1]. CL is ideally suited to microfluidic flow-injection analysis (µFIA), due to the precise temporal and space control of sample/reagent aliquots [2]. However, while CL is a sensitive technique, the ultrasmall volumes employed in µFIA lead to low emitted power, so that signal enhancement methods are required to achieve suitable detection limits. Gold and silver nanoparticles (GNPs and SNPs) may provide enhancement of optical signals due to collective oscillation of conduction electrons excited by the electromagnetic field or due to catalysis [3,4]. In this study, CL of luminol was investigated in a microflow chip with a serpentine channel of width 600 µm, depth 75 µm and length 150 mm formed in polydimethylsiloxane (PDMS) by moulding over a 3D printed master.

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Mosayyebi, A., Karabchevsky, A. and Wilkinson, J.S. (2013) Nanoparticle-enhanced chemiluminescence in micro-flow injection analysis At 6th Mediterranean Conference on Nano-Photonics (MediNano-6), France. 30 - 31 Oct 2013.

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Published date: 2013
Venue - Dates: 6th Mediterranean Conference on Nano-Photonics (MediNano-6), France, 2013-10-30 - 2013-10-31
Organisations: Optoelectronics Research Centre


Local EPrints ID: 361187
PURE UUID: e8f106c1-fdf7-40db-8971-efadabee1e7d
ORCID for J.S. Wilkinson: ORCID iD

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Date deposited: 15 Jan 2014 13:55
Last modified: 18 Jul 2017 03:06

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Author: A. Mosayyebi
Author: A. Karabchevsky
Author: J.S. Wilkinson ORCID iD

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