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Repetitive bilateral arm training and motor cortex activation in chronic stroke

Repetitive bilateral arm training and motor cortex activation in chronic stroke
Repetitive bilateral arm training and motor cortex activation in chronic stroke
Context: reorganization in central motor networks occurs during early recovery from hemiparetic stroke. In chronic stroke survivors, specific rehabilitation therapy can improve upper extremity function.

Objective: to test the hypothesis that in patients who have chronic motor impairment following stroke, specific rehabilitation therapy that improves arm function is associated with reorganization of cortical networks.

Design, setting, and patients: a randomized controlled clinical trial conducted in a US ambulatory rehabilitation program with 21 patients (median [IQR], 50.3 [34.8-77.3] months after unilateral stroke). Data were collected between 2001 and 2004.

Interventions: patients were randomly assigned to bilateral arm training with rhythmic auditory cueing (BATRAC) (n = 9) or standardized dose-matched therapeutic exercises (DMTE) (n = 12). Both were conducted for 1 hour, 3 times a week, for 6 weeks.

Main outcome measures: within 2 weeks before and after the intervention, brain activation during elbow movement assessed by functional magnetic resonance imaging (fMRI) and functional outcome assessed using arm function scores.

Results: patients in the BATRAC group but not in the DMTE group increased hemispheric activation during paretic arm movement (P = .03). Changes in activation were observed in the contralesional cerebrum and ipsilesional cerebellum (P = .009). BATRAC was associated with significant increases in activation in precentral (P < .001) and postcentral gyri (P = .03) and the cerebellum (P < .001), although 3 BATRAC patients showed no fMRI changes. Considering all patients, there were no differences in functional outcome between groups. When only BATRAC patients with fMRI response were included (n = 6), BATRAC improved arm function more than DMTE did (P = .02).

Conclusions: these preliminary findings suggest that BATRAC induces reorganization in contralesional motor networks and provide biological plausibility for repetitive bilateral training as a potential therapy for upper extremity rehabilitation in hemiparetic stroke
1538-3598
1853-1861
Luft, Andreas R.
7d63411e-0ae7-4b6b-9455-b43ba702238c
McCombe-Waller, Sandy
6c931ed9-48d3-4356-9db7-790ad6d134ba
Whitall, Jill
9761aefb-be80-4270-bc1f-0e726399376e
Forrester, Larry W.
ad7de5d6-69ae-4524-bd73-ec46cc485cae
Macko, Richard
bb9592d8-dd75-4e57-b94b-f8246158fbfb
Sorkin, John D.
d9ad991b-6e60-4fbc-af09-19f5c5cf26b3
Schulz, Jörg B.
f5517b7f-ec31-4c7d-9e5c-e190f3c5fd5e
Goldberg, Andrew P.
13b56fdc-e27b-4ab2-87ad-17099f34ddc3
Hanley, Daniel F.
eedff09c-b115-4f05-bd76-012397e1adbd
Luft, Andreas R.
7d63411e-0ae7-4b6b-9455-b43ba702238c
McCombe-Waller, Sandy
6c931ed9-48d3-4356-9db7-790ad6d134ba
Whitall, Jill
9761aefb-be80-4270-bc1f-0e726399376e
Forrester, Larry W.
ad7de5d6-69ae-4524-bd73-ec46cc485cae
Macko, Richard
bb9592d8-dd75-4e57-b94b-f8246158fbfb
Sorkin, John D.
d9ad991b-6e60-4fbc-af09-19f5c5cf26b3
Schulz, Jörg B.
f5517b7f-ec31-4c7d-9e5c-e190f3c5fd5e
Goldberg, Andrew P.
13b56fdc-e27b-4ab2-87ad-17099f34ddc3
Hanley, Daniel F.
eedff09c-b115-4f05-bd76-012397e1adbd

Luft, Andreas R., McCombe-Waller, Sandy, Whitall, Jill, Forrester, Larry W., Macko, Richard, Sorkin, John D., Schulz, Jörg B., Goldberg, Andrew P. and Hanley, Daniel F. (2004) Repetitive bilateral arm training and motor cortex activation in chronic stroke. JAMA, 292 (15), 1853-1861. (doi:10.1001/jama.292.15.1853). (PMID:15494583)

Record type: Article

Abstract

Context: reorganization in central motor networks occurs during early recovery from hemiparetic stroke. In chronic stroke survivors, specific rehabilitation therapy can improve upper extremity function.

Objective: to test the hypothesis that in patients who have chronic motor impairment following stroke, specific rehabilitation therapy that improves arm function is associated with reorganization of cortical networks.

Design, setting, and patients: a randomized controlled clinical trial conducted in a US ambulatory rehabilitation program with 21 patients (median [IQR], 50.3 [34.8-77.3] months after unilateral stroke). Data were collected between 2001 and 2004.

Interventions: patients were randomly assigned to bilateral arm training with rhythmic auditory cueing (BATRAC) (n = 9) or standardized dose-matched therapeutic exercises (DMTE) (n = 12). Both were conducted for 1 hour, 3 times a week, for 6 weeks.

Main outcome measures: within 2 weeks before and after the intervention, brain activation during elbow movement assessed by functional magnetic resonance imaging (fMRI) and functional outcome assessed using arm function scores.

Results: patients in the BATRAC group but not in the DMTE group increased hemispheric activation during paretic arm movement (P = .03). Changes in activation were observed in the contralesional cerebrum and ipsilesional cerebellum (P = .009). BATRAC was associated with significant increases in activation in precentral (P < .001) and postcentral gyri (P = .03) and the cerebellum (P < .001), although 3 BATRAC patients showed no fMRI changes. Considering all patients, there were no differences in functional outcome between groups. When only BATRAC patients with fMRI response were included (n = 6), BATRAC improved arm function more than DMTE did (P = .02).

Conclusions: these preliminary findings suggest that BATRAC induces reorganization in contralesional motor networks and provide biological plausibility for repetitive bilateral training as a potential therapy for upper extremity rehabilitation in hemiparetic stroke

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Published date: October 2004
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 361342
URI: http://eprints.soton.ac.uk/id/eprint/361342
ISSN: 1538-3598
PURE UUID: 208b128b-5afb-4710-bbb6-e232c0507492

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Date deposited: 17 Jan 2014 14:55
Last modified: 16 Jul 2019 21:14

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Contributors

Author: Andreas R. Luft
Author: Sandy McCombe-Waller
Author: Jill Whitall
Author: Larry W. Forrester
Author: Richard Macko
Author: John D. Sorkin
Author: Jörg B. Schulz
Author: Andrew P. Goldberg
Author: Daniel F. Hanley

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