Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma
Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma
There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well‐known risk factor for AD. In spontaneously hypertensive stroke‐prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age‐dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.
124-129
Bueche, Celine Z.
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Hawkes, Cheryl
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Garz, Cornelia
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Vielhaber, Stefan
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Attems, Johannes
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Knight, Robert T.
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Reymann, Klaus
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Heinze, Hans-Jochen
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Carare, Roxana O.
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Schreiber, Stefanie
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9 January 2014
Bueche, Celine Z.
f9215d60-f6bf-4cc8-9b77-0148f8202107
Hawkes, Cheryl
031a17ac-0931-4ff9-93cc-df8cb58e14f7
Garz, Cornelia
beb2ed6d-1934-4742-8693-2f433c5b9b69
Vielhaber, Stefan
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Attems, Johannes
03a5a37f-79eb-4350-b6ab-ffa1999279ab
Knight, Robert T.
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Reymann, Klaus
43dc5c96-4e78-4cc3-9ddb-1b5deb8723c2
Heinze, Hans-Jochen
e5b52444-3fcb-4abc-be1c-416bf91d7986
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Schreiber, Stefanie
0d270570-e83c-46e5-b241-04deeb2d1767
Bueche, Celine Z., Hawkes, Cheryl, Garz, Cornelia, Vielhaber, Stefan, Attems, Johannes, Knight, Robert T., Reymann, Klaus, Heinze, Hans-Jochen, Carare, Roxana O. and Schreiber, Stefanie
(2014)
Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma.
Annals of Clinical and Translational Neurology, 1 (2), .
(doi:10.1002/acn3.27).
Abstract
There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well‐known risk factor for AD. In spontaneously hypertensive stroke‐prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age‐dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.
Text
Bueche et al 2014 Annals of Clinical and Translational Neurology
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Published date: 9 January 2014
Organisations:
Faculty of Medicine
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Local EPrints ID: 361468
URI: http://eprints.soton.ac.uk/id/eprint/361468
PURE UUID: b259e819-d0f8-468c-b73e-8e58c9cfa947
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Date deposited: 21 Jan 2014 16:39
Last modified: 15 Mar 2024 03:01
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Author:
Celine Z. Bueche
Author:
Cheryl Hawkes
Author:
Cornelia Garz
Author:
Stefan Vielhaber
Author:
Johannes Attems
Author:
Robert T. Knight
Author:
Klaus Reymann
Author:
Hans-Jochen Heinze
Author:
Stefanie Schreiber
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