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Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion

Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion
Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion
The scientific literature contains evidence suggesting that women who have been treated for breast cancer may, as a result of their diagnosis, increase their phyto-oestrogen (PE) intake. In the present paper, we describe the creation of a dietary analysis database (based on Dietplan6) for the determination of dietary intakes of specific PE (daidzein, genistein, glycitein, formononetin, biochanin A, coumestrol, matairesinol and secoisolariciresinol), in a group of women previously diagnosed and treated for postmenopausal breast cancer. The design of the database, data evaluation criteria, literature data entry for 551 foods and primary analysis by LC–MS/MS of an additional thirty-four foods for which there were no published data are described. The dietary intake of 316 women previously treated for postmenopausal breast cancer informed the identification of potential food and beverage sources of PE and the bespoke dietary analysis database was created to, ultimately, quantify their PE intake. In order that PE exposure could be comprehensively described, fifty-four of the 316 subjects completed a 24 h urine collection, and their urinary excretion results allowed for the description of exposure to include those identified as ‘equol producers’.
0007-1145
2261-2268
Clarke, Don B.
9c00a914-af27-438f-bb97-17fbba022aa6
Lloyd, Antony S.
04704089-7cd3-42e1-aed6-82204b8a391a
Lawrence, Judy M.
947ab2e0-5f68-41ac-8a2b-7441b487fc14
Brown, Jonathan E.
bad765ac-571c-4038-831a-be87064b2c7d
Storey, Lesley
1c838759-06ae-488e-841c-9538a49e7776
Raats, Monique
5bf65e41-fd40-43ec-bf3b-dad0041d85f8
Rainsbury, Richard M.
08c63e08-5d1c-41c7-9c1e-83bfacc39bf7
Culliford, D.J.
25511573-74d3-422a-b0ee-dfe60f80df87
Bailey-Horne, Victoria A.
0fb01129-0b30-43cd-8743-a93c39a56c7c
Parry, Barbara M.
f9d059b3-3910-431c-a3d7-e1d2ed2b6efe
Clarke, Don B.
9c00a914-af27-438f-bb97-17fbba022aa6
Lloyd, Antony S.
04704089-7cd3-42e1-aed6-82204b8a391a
Lawrence, Judy M.
947ab2e0-5f68-41ac-8a2b-7441b487fc14
Brown, Jonathan E.
bad765ac-571c-4038-831a-be87064b2c7d
Storey, Lesley
1c838759-06ae-488e-841c-9538a49e7776
Raats, Monique
5bf65e41-fd40-43ec-bf3b-dad0041d85f8
Rainsbury, Richard M.
08c63e08-5d1c-41c7-9c1e-83bfacc39bf7
Culliford, D.J.
25511573-74d3-422a-b0ee-dfe60f80df87
Bailey-Horne, Victoria A.
0fb01129-0b30-43cd-8743-a93c39a56c7c
Parry, Barbara M.
f9d059b3-3910-431c-a3d7-e1d2ed2b6efe

Clarke, Don B., Lloyd, Antony S., Lawrence, Judy M., Brown, Jonathan E., Storey, Lesley, Raats, Monique, Rainsbury, Richard M., Culliford, D.J., Bailey-Horne, Victoria A. and Parry, Barbara M. (2013) Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion. British Journal of Nutrition, 109 (12), 2261-2268. (doi:10.1017/S0007114512004394).

Record type: Article

Abstract

The scientific literature contains evidence suggesting that women who have been treated for breast cancer may, as a result of their diagnosis, increase their phyto-oestrogen (PE) intake. In the present paper, we describe the creation of a dietary analysis database (based on Dietplan6) for the determination of dietary intakes of specific PE (daidzein, genistein, glycitein, formononetin, biochanin A, coumestrol, matairesinol and secoisolariciresinol), in a group of women previously diagnosed and treated for postmenopausal breast cancer. The design of the database, data evaluation criteria, literature data entry for 551 foods and primary analysis by LC–MS/MS of an additional thirty-four foods for which there were no published data are described. The dietary intake of 316 women previously treated for postmenopausal breast cancer informed the identification of potential food and beverage sources of PE and the bespoke dietary analysis database was created to, ultimately, quantify their PE intake. In order that PE exposure could be comprehensively described, fifty-four of the 316 subjects completed a 24 h urine collection, and their urinary excretion results allowed for the description of exposure to include those identified as ‘equol producers’.

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Published date: June 2013
Organisations: Primary Care & Population Sciences

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Local EPrints ID: 361607
URI: https://eprints.soton.ac.uk/id/eprint/361607
ISSN: 0007-1145
PURE UUID: 4d59ce9b-e509-48b5-a7b1-ce02d4bc14e3

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Date deposited: 28 Jan 2014 16:46
Last modified: 16 Jul 2019 21:13

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Contributors

Author: Don B. Clarke
Author: Antony S. Lloyd
Author: Judy M. Lawrence
Author: Jonathan E. Brown
Author: Lesley Storey
Author: Monique Raats
Author: Richard M. Rainsbury
Author: D.J. Culliford
Author: Victoria A. Bailey-Horne
Author: Barbara M. Parry

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