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Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review

Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review
Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review
Managing women who are pregnant and with a diagnosis of cervical cancer has many complex challenges. This case report describes the diagnosis and management of a patient presenting in her first trimester with stage 2B cervical cancer. In conjunction with this a literature review was undertaken using the following databases from the years 1970–2010: Embase, CINAHL, Medline and DARE. We examined the number of cases reported in the literature in which chemotherapy also was used in pregnant women with a cervical malignancy. Twenty-four papers were retrieved describing in total (including the present case) 35 cases of cervical cancer in pregnancy treated with this modality. Cisplatin therapy would seem the most reliable form of treatment, permitting a good outcome for most patients. The effect of delaying radiotherapy to permit pregnancy to fetal viability in larger tumours cannot be elucidated.
cervical cancer, pregnancy, chemotherapy, neo-adjuvant chemotherapy and radiotherapy
0301-2115
205-208
Dawood, R.
77e8f454-43a6-4470-a5c0-8fb121d49439
Instone, M.
dcc58af8-790f-4dce-8ff4-94600b39840f
Kehoe, S.
57da2877-3a40-4870-a6d7-bcc61f74d932
Dawood, R.
77e8f454-43a6-4470-a5c0-8fb121d49439
Instone, M.
dcc58af8-790f-4dce-8ff4-94600b39840f
Kehoe, S.
57da2877-3a40-4870-a6d7-bcc61f74d932

Dawood, R., Instone, M. and Kehoe, S. (2013) Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review. European Journal of Obstetrics & Gynecology and Reproductive Biology, 171 (2), 205-208. (doi:10.1016/j.ejogrb.2013.09.008). (PMID:24139541)

Record type: Article

Abstract

Managing women who are pregnant and with a diagnosis of cervical cancer has many complex challenges. This case report describes the diagnosis and management of a patient presenting in her first trimester with stage 2B cervical cancer. In conjunction with this a literature review was undertaken using the following databases from the years 1970–2010: Embase, CINAHL, Medline and DARE. We examined the number of cases reported in the literature in which chemotherapy also was used in pregnant women with a cervical malignancy. Twenty-four papers were retrieved describing in total (including the present case) 35 cases of cervical cancer in pregnancy treated with this modality. Cisplatin therapy would seem the most reliable form of treatment, permitting a good outcome for most patients. The effect of delaying radiotherapy to permit pregnancy to fetal viability in larger tumours cannot be elucidated.

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Published date: December 2013
Keywords: cervical cancer, pregnancy, chemotherapy, neo-adjuvant chemotherapy and radiotherapy
Organisations: Faculty of Medicine

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Local EPrints ID: 361709
URI: http://eprints.soton.ac.uk/id/eprint/361709
ISSN: 0301-2115
PURE UUID: fb4ff3c4-8592-4b65-99e7-d17e839a0625

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Date deposited: 30 Jan 2014 16:24
Last modified: 11 Dec 2020 17:33

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Contributors

Author: R. Dawood
Author: M. Instone
Author: S. Kehoe

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