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Comparative cost-effectiveness models for the treatment of multiple myeloma

Comparative cost-effectiveness models for the treatment of multiple myeloma
Comparative cost-effectiveness models for the treatment of multiple myeloma
Objectives: To compare cost effectiveness models for the first-line treatment of multiple myeloma, and explore the differences between the models’ structure, parameters, assumptions and results.

Methods: Three cost effectiveness models for the treatment of multiple myeloma, were compared that had been developed to inform resource allocation in the UK for the chemotherapy regimens bortezomib, melphalan and prednisolone (BMP); and melphalan, prednisolone and thalidomide (MPT) versus melphalan and prednisolone (MP). The models used alternative approaches and assumptions to estimate the overall survival and progression-free survival for each of the interventions. Through the use of sensitivity analyses, the most influential parameters and assumptions of each of the models were identified.

Results: The models developed by the manufacturers gave conflicting results, with each manufacturer favouring their drug. The differences between the model results were determined by two parameters: the hazard ratio for overall survival for MPT vs. MP and the cost of bortezomib.

Conclusions: Using models developed for assessing treatments for multiple myeloma we demonstrated that it was feasible to compare models, which then aided decision makers in making reimbursement decisions.
cost-utility analysis, thalidomide, bortezomib, multiple myeloma
0266-4623
1-8
Cooper, K.
6b37f95e-daae-4b87-9f79-0fabd4eb8f6b
Picot, J.
324d6f20-a105-49fd-9fb0-88791be84ada
Bryant, J.
508f497c-8b5a-468f-a37d-be9c26e4e49d
Clegg, A.
838091f5-39df-4dbe-a369-675b26f2301b
Cooper, K.
6b37f95e-daae-4b87-9f79-0fabd4eb8f6b
Picot, J.
324d6f20-a105-49fd-9fb0-88791be84ada
Bryant, J.
508f497c-8b5a-468f-a37d-be9c26e4e49d
Clegg, A.
838091f5-39df-4dbe-a369-675b26f2301b

Cooper, K., Picot, J., Bryant, J. and Clegg, A. (2014) Comparative cost-effectiveness models for the treatment of multiple myeloma. International Journal of Technology Assessment in Health Care, 1-8. (doi:10.1017/S0266462313000615). (PMID:24451119)

Record type: Article

Abstract

Objectives: To compare cost effectiveness models for the first-line treatment of multiple myeloma, and explore the differences between the models’ structure, parameters, assumptions and results.

Methods: Three cost effectiveness models for the treatment of multiple myeloma, were compared that had been developed to inform resource allocation in the UK for the chemotherapy regimens bortezomib, melphalan and prednisolone (BMP); and melphalan, prednisolone and thalidomide (MPT) versus melphalan and prednisolone (MP). The models used alternative approaches and assumptions to estimate the overall survival and progression-free survival for each of the interventions. Through the use of sensitivity analyses, the most influential parameters and assumptions of each of the models were identified.

Results: The models developed by the manufacturers gave conflicting results, with each manufacturer favouring their drug. The differences between the model results were determined by two parameters: the hazard ratio for overall survival for MPT vs. MP and the cost of bortezomib.

Conclusions: Using models developed for assessing treatments for multiple myeloma we demonstrated that it was feasible to compare models, which then aided decision makers in making reimbursement decisions.

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More information

e-pub ahead of print date: 22 January 2014
Keywords: cost-utility analysis, thalidomide, bortezomib, multiple myeloma
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 361727
URI: http://eprints.soton.ac.uk/id/eprint/361727
ISSN: 0266-4623
PURE UUID: 95899bd6-e767-4804-87ed-2f859f8b2f39
ORCID for J. Picot: ORCID iD orcid.org/0000-0001-5987-996X

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Date deposited: 31 Jan 2014 15:04
Last modified: 26 Nov 2019 01:47

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Contributors

Author: K. Cooper
Author: J. Picot ORCID iD
Author: J. Bryant
Author: A. Clegg

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