Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease
Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease
Omega-3 (n?3) polyunsaturated fatty acids (n?3 PUFAs) have well documented anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory diseases. Here we discuss the effects of n?3 PUFAs on various inflammatory pathways and how this leads to alterations in the function of inflammatory cells, most importantly endothelial cells and leukocytes. Strong evidence indicates n?3 PUFAs are beneficial as a dietary supplement in certain diseases such as rheumatoid arthritis; however for other conditions such as asthma, the data are less robust. A clearer understanding of the pharmacology of n?3 PUFAs will help to establish targets to modulate chronic inflammatory diseases.
omega-3 polyunsaturated fatty acid, eicosapentaenoic acid, docosahexaenoic acid, inflammation, eicosanoid, resolvin
272-282
Yates, C.M.
d1bf844a-a526-4dff-9528-52666d4e8278
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Rainger, G.E.
0bbadb52-915e-4217-aa9b-e1974eda8031
March 2014
Yates, C.M.
d1bf844a-a526-4dff-9528-52666d4e8278
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Rainger, G.E.
0bbadb52-915e-4217-aa9b-e1974eda8031
Yates, C.M., Calder, P.C. and Rainger, G.E.
(2014)
Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease.
Pharmacology & Therapeutics, 141 (3), .
(doi:10.1016/j.pharmthera.2013.10.010).
(PMID:24201219)
Abstract
Omega-3 (n?3) polyunsaturated fatty acids (n?3 PUFAs) have well documented anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory diseases. Here we discuss the effects of n?3 PUFAs on various inflammatory pathways and how this leads to alterations in the function of inflammatory cells, most importantly endothelial cells and leukocytes. Strong evidence indicates n?3 PUFAs are beneficial as a dietary supplement in certain diseases such as rheumatoid arthritis; however for other conditions such as asthma, the data are less robust. A clearer understanding of the pharmacology of n?3 PUFAs will help to establish targets to modulate chronic inflammatory diseases.
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Published date: March 2014
Keywords:
omega-3 polyunsaturated fatty acid, eicosapentaenoic acid, docosahexaenoic acid, inflammation, eicosanoid, resolvin
Organisations:
Human Development & Health
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Local EPrints ID: 361817
URI: http://eprints.soton.ac.uk/id/eprint/361817
ISSN: 0163-7258
PURE UUID: f24a7136-f9b3-4f67-8ceb-fbc2e1480f86
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Date deposited: 04 Feb 2014 14:36
Last modified: 15 Mar 2024 02:50
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Author:
C.M. Yates
Author:
G.E. Rainger
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