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Long-term outcomes of Fine Needle Diathermy for established corneal neovascularisation

Long-term outcomes of Fine Needle Diathermy for established corneal neovascularisation
Long-term outcomes of Fine Needle Diathermy for established corneal neovascularisation
BACKGROUND/AIMS:
Corneal neovascularisation (CoNV) can lead to significant ocular comorbidity with reduction in vision and cosmesis. A number of techniques have been described to reduce CoNV, but these can be expensive. Our study aimed to determine the safety, efficacy and long-term outcomes of fine needle diathermy (FND) for CoNV.

METHODS:
A 5-year retrospective study identified all cases of FND. Indications, intraoperative complications, and postoperative visual acuity, after treatment and retreatments, were documented, along with the procedure time. Evidence of regression and number of retreatments were identified.

RESULTS:
56 eyes from 52 patients underwent FND for CoNV. The main indications included herpes simplex keratitis (HSK) (53%, n=25) and microbial keratitis/peripheral ulcerative keratitis (13%, n=6). Pretreatment acuity was significantly correlated with extent of CoNV (p=0.044). One complication was noted during the procedure-an intrastromal and subconjunctival haemorrhage (rate 2%). 68.1% of patients demonstrated regression at first follow-up (mean 6.9 weeks), and 89.3% (n=42) showed regression with two or less treatments. Mean post-FND acuity was 0.72 (range -0.2-3.0) vs 0.82 (-0.2-3.0) preprocedure (p=0.08). VA improved in the HSK subgroup (p=0.012). Mean follow-up was 18.9 months (range 1-56 months).

CONCLUSIONS:
In the largest case series reported, FND appears to be a safe and effective technique in the long term to induce regression of CoNV, with significant improvement in the VA of patients with HSK.
0007-1161
Hossain, P.
563de5fc-84ad-4539-9228-bde0237eaf51
Trikha, S.
caa190e9-1287-4cc5-b359-92e8fd140801
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Anderson, D. F.
3fec3e41-b5d1-43ea-86bb-dc417308b8db
Hossain, P.
563de5fc-84ad-4539-9228-bde0237eaf51
Trikha, S.
caa190e9-1287-4cc5-b359-92e8fd140801
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Anderson, D. F.
3fec3e41-b5d1-43ea-86bb-dc417308b8db

Hossain, P., Trikha, S., Osmond, Clive and Anderson, D. F. (2014) Long-term outcomes of Fine Needle Diathermy for established corneal neovascularisation. British Journal of Ophthalmology. (doi:10.1136/bjophthalmol-2013-303729). (PMID:24457357)

Record type: Article

Abstract

BACKGROUND/AIMS:
Corneal neovascularisation (CoNV) can lead to significant ocular comorbidity with reduction in vision and cosmesis. A number of techniques have been described to reduce CoNV, but these can be expensive. Our study aimed to determine the safety, efficacy and long-term outcomes of fine needle diathermy (FND) for CoNV.

METHODS:
A 5-year retrospective study identified all cases of FND. Indications, intraoperative complications, and postoperative visual acuity, after treatment and retreatments, were documented, along with the procedure time. Evidence of regression and number of retreatments were identified.

RESULTS:
56 eyes from 52 patients underwent FND for CoNV. The main indications included herpes simplex keratitis (HSK) (53%, n=25) and microbial keratitis/peripheral ulcerative keratitis (13%, n=6). Pretreatment acuity was significantly correlated with extent of CoNV (p=0.044). One complication was noted during the procedure-an intrastromal and subconjunctival haemorrhage (rate 2%). 68.1% of patients demonstrated regression at first follow-up (mean 6.9 weeks), and 89.3% (n=42) showed regression with two or less treatments. Mean post-FND acuity was 0.72 (range -0.2-3.0) vs 0.82 (-0.2-3.0) preprocedure (p=0.08). VA improved in the HSK subgroup (p=0.012). Mean follow-up was 18.9 months (range 1-56 months).

CONCLUSIONS:
In the largest case series reported, FND appears to be a safe and effective technique in the long term to induce regression of CoNV, with significant improvement in the VA of patients with HSK.

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Br J Ophthalmol-2014-Trikha-bjophthalmol-2013-303729.pdf - Author's Original
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More information

e-pub ahead of print date: 23 January 2014
Published date: 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 361820
URI: https://eprints.soton.ac.uk/id/eprint/361820
ISSN: 0007-1161
PURE UUID: 8c7fa80a-059c-4c42-b91f-b59e713a4da7
ORCID for P. Hossain: ORCID iD orcid.org/0000-0002-3131-2395
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 04 Feb 2014 15:09
Last modified: 12 Nov 2019 01:59

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