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Small head circumference at birth and early age at adiposity rebound

Small head circumference at birth and early age at adiposity rebound
Small head circumference at birth and early age at adiposity rebound
Aims

The adiposity rebound is the age in childhood when body mass index is at a minimum before increasing again. The age at rebound is highly variable. An early age is associated with increased obesity in later childhood and adult life. We have reported that an early rebound is predicted by low weight gain between birth and 1 year of age and resulting low body mass index at 1 year. Here, we examine whether age at adiposity rebound is determined by influences during infancy or is a consequence of foetal growth. Our hypothesis was that measurements of body size at birth are related to age at adiposity rebound.

Methods

Longitudinal study of 2877 children born in Helsinki, Finland, during 1934–1944.

Results

Early age at adiposity rebound was associated with small head circumference and biparietal diameter at birth, but not with other measurements of body size at birth. The mean age at adiposity rebound rose from 5.8 years in babies with a head circumference of ?33 cm to 6.2 in babies with a head circumference of >36 cm (P for trend = 0.007). The association between thinness in infancy and early rebound became apparent at 6 months of age. It was not associated with adverse living conditions. In a simultaneous regression, small head circumference at birth, high mother's body mass index and tall maternal stature each had statistically significant trends with early adiposity rebound (P = 0.002, <0.001, 0.004).

Conclusion

We hypothesize that the small head size at birth that preceded an early adiposity rebound was the result of inability to sustain a rapid intra-uterine growth trajectory initiated in association with large maternal body size. This was followed by catch-up growth in infancy, and we hypothesize that this depleted the infant's fat stores.
adiposity rebound, foetal growth, infant growth
1748-1708
154-160
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Lampl, M.
cb9cb5d9-91a5-4315-952e-f3cd6b724085
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Lampl, M.
cb9cb5d9-91a5-4315-952e-f3cd6b724085
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44

Eriksson, J.G., Kajantie, E., Lampl, M., Osmond, C. and Barker, D.J. (2014) Small head circumference at birth and early age at adiposity rebound. Acta Physiologica, 210 (1), 154-160. (doi:10.1111/apha.12142). (PMID:23796386)

Record type: Article

Abstract

Aims

The adiposity rebound is the age in childhood when body mass index is at a minimum before increasing again. The age at rebound is highly variable. An early age is associated with increased obesity in later childhood and adult life. We have reported that an early rebound is predicted by low weight gain between birth and 1 year of age and resulting low body mass index at 1 year. Here, we examine whether age at adiposity rebound is determined by influences during infancy or is a consequence of foetal growth. Our hypothesis was that measurements of body size at birth are related to age at adiposity rebound.

Methods

Longitudinal study of 2877 children born in Helsinki, Finland, during 1934–1944.

Results

Early age at adiposity rebound was associated with small head circumference and biparietal diameter at birth, but not with other measurements of body size at birth. The mean age at adiposity rebound rose from 5.8 years in babies with a head circumference of ?33 cm to 6.2 in babies with a head circumference of >36 cm (P for trend = 0.007). The association between thinness in infancy and early rebound became apparent at 6 months of age. It was not associated with adverse living conditions. In a simultaneous regression, small head circumference at birth, high mother's body mass index and tall maternal stature each had statistically significant trends with early adiposity rebound (P = 0.002, <0.001, 0.004).

Conclusion

We hypothesize that the small head size at birth that preceded an early adiposity rebound was the result of inability to sustain a rapid intra-uterine growth trajectory initiated in association with large maternal body size. This was followed by catch-up growth in infancy, and we hypothesize that this depleted the infant's fat stores.

Full text not available from this repository.

More information

e-pub ahead of print date: 14 July 2013
Published date: January 2014
Keywords: adiposity rebound, foetal growth, infant growth
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 361835
URI: http://eprints.soton.ac.uk/id/eprint/361835
ISSN: 1748-1708
PURE UUID: 9ecb4f3c-07ca-43b4-aaec-725c80f1ae3d
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 04 Feb 2014 14:57
Last modified: 18 Feb 2021 16:45

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Contributors

Author: J.G. Eriksson
Author: E. Kajantie
Author: M. Lampl
Author: C. Osmond ORCID iD
Author: D.J. Barker

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