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Cohesin and Cdk1: an anaphase barricade

Cohesin and Cdk1: an anaphase barricade
Cohesin and Cdk1: an anaphase barricade
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.

1465-7392
106-108
Jones, KT
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4
Jones, KT
73e8e2b5-cd67-4691-b1a9-4e7bc9066af4

Jones, KT (2010) Cohesin and Cdk1: an anaphase barricade. Nature Cell Biology, 12 (2), 106-108. (doi:10.1038/ncb0210-106).

Record type: Article

Abstract

Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.

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Published date: 2010
Organisations: Centre for Biological Sciences
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Identifiers

Local EPrints ID: 361978
URI: http://eprints.soton.ac.uk/id/eprint/361978
DOI: doi:10.1038/ncb0210-106
ISSN: 1465-7392
PURE UUID: 6c7496a3-fc08-4cbc-9ede-0659c924d3f4
ORCID for KT Jones: ORCID iD orcid.org/0000-0002-0294-0851

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Date deposited: 10 Feb 2014 13:09
Last modified: 14 Mar 2024 15:59

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Author: KT Jones ORCID iD

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