Rhinoviruses infect the lower airways
Rhinoviruses infect the lower airways
Rhinoviruses are the major cause of the common cold and a trigger of acute asthma exacerbations. Whether these exacerbations result from direct infection of the lower airway or from indirect mechanisms consequent on infection of the upper airway alone is currently unknown. Lower respiratory infection was investigated in vitro by exposing primary human bronchial epithelial cells to rhinoviruses and in vivo after experimental upper respiratory infection of human volunteers. Bronchial infection was confirmed by both approaches. Furthermore, rhinoviruses induced production of interleukin-6, -8, and -16 and RANTES and were cytotoxic to cultured respiratory epithelium. This evidence strongly supports a direct lower respiratory epithelial reaction as the initial event in the induction of rhinovirus-mediated asthma exacerbations. The frequency of infection and the nature of the inflammatory response observed are similar to those of the upper respiratory tract, suggesting that rhinovirus infections may be one of the most important causes of lower in addition to upper respiratory disease.
1875-1884
Papadopoulos, N.G.
fac5aea9-7ee2-4579-90c8-e547b6a4bdf7
Bates, P.J.
55701138-5431-433d-a502-a54c5fd48829
Bardin, P.G.
92b18c26-9432-4605-954d-85e6d3f1cdbe
Papi, A.
e64601e5-163a-416d-867d-c548aa80dd75
Leir, S.H.
8b286b20-8054-4fff-a8e5-c5e3a13bcbba
Fraenkel, D.J.
a9d3abed-7dde-4b16-90c7-f75813350a89
Meyer, J.
50b8fd43-2b12-481c-bb05-9e4bfc38f44a
Lackie, P.M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Sanderson, G.
18de77c4-22e8-4446-abb9-d6281d99ac5d
Holgate, S.T.
48e197d1-3681-43c1-9a3e-478311f6618d
Johnston, S.L.
f31c4376-1118-4eba-807d-9264c8df10a1
6 June 2000
Papadopoulos, N.G.
fac5aea9-7ee2-4579-90c8-e547b6a4bdf7
Bates, P.J.
55701138-5431-433d-a502-a54c5fd48829
Bardin, P.G.
92b18c26-9432-4605-954d-85e6d3f1cdbe
Papi, A.
e64601e5-163a-416d-867d-c548aa80dd75
Leir, S.H.
8b286b20-8054-4fff-a8e5-c5e3a13bcbba
Fraenkel, D.J.
a9d3abed-7dde-4b16-90c7-f75813350a89
Meyer, J.
50b8fd43-2b12-481c-bb05-9e4bfc38f44a
Lackie, P.M.
4afbbe1a-22a6-4ceb-8cad-f3696dc43a7a
Sanderson, G.
18de77c4-22e8-4446-abb9-d6281d99ac5d
Holgate, S.T.
48e197d1-3681-43c1-9a3e-478311f6618d
Johnston, S.L.
f31c4376-1118-4eba-807d-9264c8df10a1
Papadopoulos, N.G., Bates, P.J., Bardin, P.G., Papi, A., Leir, S.H., Fraenkel, D.J., Meyer, J., Lackie, P.M., Sanderson, G., Holgate, S.T. and Johnston, S.L.
(2000)
Rhinoviruses infect the lower airways.
The Journal of Infectious Diseases, 181 (6), .
(doi:10.1086/315513).
(PMID:10837165)
Abstract
Rhinoviruses are the major cause of the common cold and a trigger of acute asthma exacerbations. Whether these exacerbations result from direct infection of the lower airway or from indirect mechanisms consequent on infection of the upper airway alone is currently unknown. Lower respiratory infection was investigated in vitro by exposing primary human bronchial epithelial cells to rhinoviruses and in vivo after experimental upper respiratory infection of human volunteers. Bronchial infection was confirmed by both approaches. Furthermore, rhinoviruses induced production of interleukin-6, -8, and -16 and RANTES and were cytotoxic to cultured respiratory epithelium. This evidence strongly supports a direct lower respiratory epithelial reaction as the initial event in the induction of rhinovirus-mediated asthma exacerbations. The frequency of infection and the nature of the inflammatory response observed are similar to those of the upper respiratory tract, suggesting that rhinovirus infections may be one of the most important causes of lower in addition to upper respiratory disease.
This record has no associated files available for download.
More information
e-pub ahead of print date: 5 June 2000
Published date: 6 June 2000
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 362242
URI: http://eprints.soton.ac.uk/id/eprint/362242
ISSN: 0022-1899
PURE UUID: f13d14dc-a001-4015-8609-fb68fbf9b0e6
Catalogue record
Date deposited: 19 Feb 2014 13:16
Last modified: 15 Mar 2024 02:46
Export record
Altmetrics
Contributors
Author:
N.G. Papadopoulos
Author:
P.J. Bates
Author:
P.G. Bardin
Author:
A. Papi
Author:
S.H. Leir
Author:
D.J. Fraenkel
Author:
J. Meyer
Author:
G. Sanderson
Author:
S.T. Holgate
Author:
S.L. Johnston
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics