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Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects

Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects
Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects
Human rhinoviruses (HRV) cause the majority of common colds and are etiologically linked with changes in lower airways physiology and asthma exacerbations. We hypothesized that changes in bronchial mucosal inflammatory cell populations may be responsible for HRV-induced changes in airway reactivity. We examined bronchial mucosal biopsies during experimental infections with HRV serotype 16 and measured changes in histamine reactivity. Seventeen adult volunteers (six atopic asthmatics) had baseline measurements of histamine reactivity and fiberoptic bronchoscopic biopsies, followed 2 wk later by viral inoculation. Further bronchial biopsies were taken on Day 4 of the infection and 6 to 10 wk later. Mast cells, eosinophils, lymphocytes, and neutrophils were quantified by immunohistochemical techniques. Infection was documented by viral culture, seroconversion, and symptoms. An increase in histamine responsiveness during the cold (p = 0.048) was accompanied by increases in submucosal lymphocytes (p = 0.050). There was a subsequent decrease in submucosal and epithelial lymphocytes in convalescence (p = 0.028; p = 0.030). There was an increase in epithelial eosinophils with the cold (p = 0.042), and in asthmatics this appeared to persist into convalescence. A peripheral blood lymphopenia correlated with increased responsiveness (r = 0.062, p = 0.014). Rhinoviral colds are associated with a bronchial mucosal lymphocytic and eosinophilic infiltrate that may be related to changes in airway responsiveness and asthma exacerbations.
1073-449X
879-886
Fraenkel, D.J.
a9d3abed-7dde-4b16-90c7-f75813350a89
Bardin, P.G.
92b18c26-9432-4605-954d-85e6d3f1cdbe
Sanderson, G.
18de77c4-22e8-4446-abb9-d6281d99ac5d
Lampe, F.
90b9125d-0f6f-4f07-b774-3325e6c5135e
Johnston, S.L.
f31c4376-1118-4eba-807d-9264c8df10a1
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Fraenkel, D.J.
a9d3abed-7dde-4b16-90c7-f75813350a89
Bardin, P.G.
92b18c26-9432-4605-954d-85e6d3f1cdbe
Sanderson, G.
18de77c4-22e8-4446-abb9-d6281d99ac5d
Lampe, F.
90b9125d-0f6f-4f07-b774-3325e6c5135e
Johnston, S.L.
f31c4376-1118-4eba-807d-9264c8df10a1
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Fraenkel, D.J., Bardin, P.G., Sanderson, G., Lampe, F., Johnston, S.L. and Holgate, S.T. (1995) Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. American Journal of Respiratory and Critical Care Medicine, 151 (3), part 1, 879-886. (doi:10.1164/ajrccm/151.3_Pt_1.879). (PMID:7881686)

Record type: Article

Abstract

Human rhinoviruses (HRV) cause the majority of common colds and are etiologically linked with changes in lower airways physiology and asthma exacerbations. We hypothesized that changes in bronchial mucosal inflammatory cell populations may be responsible for HRV-induced changes in airway reactivity. We examined bronchial mucosal biopsies during experimental infections with HRV serotype 16 and measured changes in histamine reactivity. Seventeen adult volunteers (six atopic asthmatics) had baseline measurements of histamine reactivity and fiberoptic bronchoscopic biopsies, followed 2 wk later by viral inoculation. Further bronchial biopsies were taken on Day 4 of the infection and 6 to 10 wk later. Mast cells, eosinophils, lymphocytes, and neutrophils were quantified by immunohistochemical techniques. Infection was documented by viral culture, seroconversion, and symptoms. An increase in histamine responsiveness during the cold (p = 0.048) was accompanied by increases in submucosal lymphocytes (p = 0.050). There was a subsequent decrease in submucosal and epithelial lymphocytes in convalescence (p = 0.028; p = 0.030). There was an increase in epithelial eosinophils with the cold (p = 0.042), and in asthmatics this appeared to persist into convalescence. A peripheral blood lymphopenia correlated with increased responsiveness (r = 0.062, p = 0.014). Rhinoviral colds are associated with a bronchial mucosal lymphocytic and eosinophilic infiltrate that may be related to changes in airway responsiveness and asthma exacerbations.

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Published date: March 1995
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 362243
URI: http://eprints.soton.ac.uk/id/eprint/362243
ISSN: 1073-449X
PURE UUID: 40ad6ac8-d056-4d78-9247-00a259ade989

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Date deposited: 19 Feb 2014 13:31
Last modified: 18 Jul 2017 02:54

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Contributors

Author: D.J. Fraenkel
Author: P.G. Bardin
Author: G. Sanderson
Author: F. Lampe
Author: S.L. Johnston
Author: S.T. Holgate

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