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Bacterial biofilms and periprosthetic infections

Bacterial biofilms and periprosthetic infections
Bacterial biofilms and periprosthetic infections
The diagnosis and treatment of periprosthetic infection after joint arthroplasty is often frustrating for the orthopaedic surgeon. The application of certain diagnostic criteria and different treatment strategies can be better directed if these infections are placed in the context of microbial biofilms. An understanding of this biofilm mode of microbial infection can help to explain the phenomenon of culture-negative infection as well as provide an understanding of why certain treatment modalities often fail. Continued basic research into the role of biofilms in infection will likely provide improved strategies for the clinical diagnosis and treatment of periprosthetic infection.
0021-9355
2223-2229
Arnold, William V
97a31b4b-bd60-4a11-961c-1ee1aeb5c7a6
Shirtliff, Mark E
62549472-d2fa-45c5-9e1c-7d31fe365208
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Arnold, William V
97a31b4b-bd60-4a11-961c-1ee1aeb5c7a6
Shirtliff, Mark E
62549472-d2fa-45c5-9e1c-7d31fe365208
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f

Arnold, William V, Shirtliff, Mark E and Stoodley, Paul (2013) Bacterial biofilms and periprosthetic infections. Journal of Bone and Joint Surgery, British Volume, 95 (24), 2223-2229. (PMID:24498639)

Record type: Article

Abstract

The diagnosis and treatment of periprosthetic infection after joint arthroplasty is often frustrating for the orthopaedic surgeon. The application of certain diagnostic criteria and different treatment strategies can be better directed if these infections are placed in the context of microbial biofilms. An understanding of this biofilm mode of microbial infection can help to explain the phenomenon of culture-negative infection as well as provide an understanding of why certain treatment modalities often fail. Continued basic research into the role of biofilms in infection will likely provide improved strategies for the clinical diagnosis and treatment of periprosthetic infection.

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More information

Published date: 18 December 2013
Organisations: nCATS Group

Identifiers

Local EPrints ID: 362368
URI: https://eprints.soton.ac.uk/id/eprint/362368
ISSN: 0021-9355
PURE UUID: 8a5ef7c7-4195-4ec6-b161-e1124b13a98b

Catalogue record

Date deposited: 24 Feb 2014 12:03
Last modified: 18 Jul 2017 02:53

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Contributors

Author: William V Arnold
Author: Mark E Shirtliff
Author: Paul Stoodley

University divisions

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