Small-molecule inhibitors of myosin proteins
Small-molecule inhibitors of myosin proteins
Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular processes, from intracellular trafficking to cell motility, and are implicated in several human diseases (e.g., cancer, hypertrophic cardiomyopathy, deafness and many neurological disorders). Potent and selective myosin inhibitors are, therefore, not only a tool for understanding myosin function, but are also a resource for developing treatments for diseases involving myosin dysfunction or overactivity. This review will provide a brief overview of the characteristics and scientific/therapeutic applications of the presently identified small-molecule myosin inhibitors before discussing the future of myosin inhibitor and activator design
41-52
Bond, L.M.
d3183c31-9b60-4091-97d7-bc1085a3c61b
Tumbarello, D.A.
75c6932e-fdbf-4d3c-bb4f-48fbbdba93a2
Kendrick-Jones, J.
8a61732b-b80d-4bfd-b60c-1948b08af3b2
Buss, F.
69a6f70a-6506-4050-85af-89d61522fdfb
January 2013
Bond, L.M.
d3183c31-9b60-4091-97d7-bc1085a3c61b
Tumbarello, D.A.
75c6932e-fdbf-4d3c-bb4f-48fbbdba93a2
Kendrick-Jones, J.
8a61732b-b80d-4bfd-b60c-1948b08af3b2
Buss, F.
69a6f70a-6506-4050-85af-89d61522fdfb
Bond, L.M., Tumbarello, D.A., Kendrick-Jones, J. and Buss, F.
(2013)
Small-molecule inhibitors of myosin proteins.
Future Medicinal Chemistry, 5 (1), .
(doi:10.4155/fmc.12.185).
(PMID:23256812)
Abstract
Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular processes, from intracellular trafficking to cell motility, and are implicated in several human diseases (e.g., cancer, hypertrophic cardiomyopathy, deafness and many neurological disorders). Potent and selective myosin inhibitors are, therefore, not only a tool for understanding myosin function, but are also a resource for developing treatments for diseases involving myosin dysfunction or overactivity. This review will provide a brief overview of the characteristics and scientific/therapeutic applications of the presently identified small-molecule myosin inhibitors before discussing the future of myosin inhibitor and activator design
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Published date: January 2013
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 362399
URI: http://eprints.soton.ac.uk/id/eprint/362399
ISSN: 1756-8919
PURE UUID: 00c90563-cb2f-40bf-b024-d052509e799c
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Date deposited: 22 Aug 2014 08:21
Last modified: 15 Mar 2024 03:50
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Author:
L.M. Bond
Author:
J. Kendrick-Jones
Author:
F. Buss
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