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ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells.

ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells.
ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells.
The extracellular matrix (ECM) has a key role in facilitating the progression of ovarian cancer and we have shown recently that the secreted ECM protein TGFBI modulates the response of ovarian cancer to paclitaxel-induced cell death.
cell adhesion, chemotherapy, integrin, ovarian cancer, extracellular matrix, integrin receptor
1-15
Tumbarello, David A.
75c6932e-fdbf-4d3c-bb4f-48fbbdba93a2
Temple, Jillian
4f60f01e-a864-477e-a995-a83f67ebe388
Brenton, James D.
834c3a0f-a453-4de5-908d-c5c21f1533af
Tumbarello, David A.
75c6932e-fdbf-4d3c-bb4f-48fbbdba93a2
Temple, Jillian
4f60f01e-a864-477e-a995-a83f67ebe388
Brenton, James D.
834c3a0f-a453-4de5-908d-c5c21f1533af

Tumbarello, David A., Temple, Jillian and Brenton, James D. (2012) ß3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells. Molecular Cancer, 11 (36), 1-15. (doi:10.1186/1476-4598-11-36). (PMID:22640878)

Record type: Article

Abstract

The extracellular matrix (ECM) has a key role in facilitating the progression of ovarian cancer and we have shown recently that the secreted ECM protein TGFBI modulates the response of ovarian cancer to paclitaxel-induced cell death.

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Published date: 28 May 2012
Keywords: cell adhesion, chemotherapy, integrin, ovarian cancer, extracellular matrix, integrin receptor
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 362408
URI: http://eprints.soton.ac.uk/id/eprint/362408
PURE UUID: cd9e0399-a79a-478b-91c4-ba6c7c5834ef
ORCID for David A. Tumbarello: ORCID iD orcid.org/0000-0002-5169-0561

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Date deposited: 21 Aug 2014 15:05
Last modified: 15 Mar 2024 03:50

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Contributors

Author: Jillian Temple
Author: James D. Brenton

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