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A lab-on-chip approach for monitoring the electrochemical activity of biorealistic cell cultures

A lab-on-chip approach for monitoring the electrochemical activity of biorealistic cell cultures
A lab-on-chip approach for monitoring the electrochemical activity of biorealistic cell cultures
The objective of any cell culturing platform is to decipher the in vivo functionality of native tissue in order to deliver reliable cell models for disease and pharmacological studies and eventually in patient-specific tissue engineering. We present a new perspective in lab-on-chip implementations for cell culturing, emphasizing on a versatile technology for cell micropatterning that can integrate electrical and pH monitoring modalities to record extracellular activity. We employ Parylene C, a highly biocompatible material, as a flexible culture substrate that controls the cellular microtopography and promotes a more in vivo-like morphology of neonatal rat ventricular myocytes. Moreover, we transfer the patterning technology on commercially available Multi-Electrode arrays to highlight the potential of integration with products customly used for extracellular electrical recordings.
Finally, we implement flexible Parylene sensors for spatiotemporal pH monitoring, using the material both as a support medium and as a sensing membrane. Integration of these three attributes may deliver a compact solution with high scientific and commercial impact.
Trantidou, T.
1a2705ad-366d-432b-be5f-523d1303930c
Tariq, M.
1d022f7f-e171-4289-ab55-5a18049d3167
Pintot, K.
8499cea5-7ef9-4a32-b26a-58fef4c5e682
Toumazou, C.
52728165-8fe5-4c54-9fad-e9ccc4423dd6
Terracciano, C.
b8db4556-6cd3-4dac-b667-2924e3bf8ce5
Prodromakis, T.
d58c9c10-9d25-4d22-b155-06c8437acfbf
Trantidou, T.
1a2705ad-366d-432b-be5f-523d1303930c
Tariq, M.
1d022f7f-e171-4289-ab55-5a18049d3167
Pintot, K.
8499cea5-7ef9-4a32-b26a-58fef4c5e682
Toumazou, C.
52728165-8fe5-4c54-9fad-e9ccc4423dd6
Terracciano, C.
b8db4556-6cd3-4dac-b667-2924e3bf8ce5
Prodromakis, T.
d58c9c10-9d25-4d22-b155-06c8437acfbf

Trantidou, T., Tariq, M., Pintot, K., Toumazou, C., Terracciano, C. and Prodromakis, T. (2014) A lab-on-chip approach for monitoring the electrochemical activity of biorealistic cell cultures At IEEE ISCAS, CAS-FEST: Circuits & Systems Society Forum on Emerging & Selected Topics, Australia. 04 - 05 Jun 2014.

Record type: Conference or Workshop Item (Other)

Abstract

The objective of any cell culturing platform is to decipher the in vivo functionality of native tissue in order to deliver reliable cell models for disease and pharmacological studies and eventually in patient-specific tissue engineering. We present a new perspective in lab-on-chip implementations for cell culturing, emphasizing on a versatile technology for cell micropatterning that can integrate electrical and pH monitoring modalities to record extracellular activity. We employ Parylene C, a highly biocompatible material, as a flexible culture substrate that controls the cellular microtopography and promotes a more in vivo-like morphology of neonatal rat ventricular myocytes. Moreover, we transfer the patterning technology on commercially available Multi-Electrode arrays to highlight the potential of integration with products customly used for extracellular electrical recordings.
Finally, we implement flexible Parylene sensors for spatiotemporal pH monitoring, using the material both as a support medium and as a sensing membrane. Integration of these three attributes may deliver a compact solution with high scientific and commercial impact.

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More information

e-pub ahead of print date: June 2014
Venue - Dates: IEEE ISCAS, CAS-FEST: Circuits & Systems Society Forum on Emerging & Selected Topics, Australia, 2014-06-04 - 2014-06-05
Organisations: Nanoelectronics and Nanotechnology

Identifiers

Local EPrints ID: 362470
URI: http://eprints.soton.ac.uk/id/eprint/362470
PURE UUID: 65e24202-e8f9-4bf2-96c5-31a7dd4bae3e

Catalogue record

Date deposited: 25 Feb 2014 12:44
Last modified: 18 Jul 2017 02:51

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Contributors

Author: T. Trantidou
Author: M. Tariq
Author: K. Pintot
Author: C. Toumazou
Author: C. Terracciano
Author: T. Prodromakis

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