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Metastable zone widths, conformational multiplicity, and seeding

Metastable zone widths, conformational multiplicity, and seeding
Metastable zone widths, conformational multiplicity, and seeding
The propensity for crystallisation of acetanilides and propionanilides was compared both by polythermal metastable zone width measurements and by isothermal induction time measurements. Although there were clear relationships between the metastable zone widths and the conformational multiplicity in some cases, they broke down for the chloroacylanilides. This failure could not be fully accounted for by the difference in the crystal structures of the chloro compounds. A surprising dependence of crystal size on seeding effectiveness could explain some of the crystallisation behaviour, particularly for the induction period measurements.
578-584
Threlfall, Terence L.
dc1fe3b2-c0c1-465c-942f-dbd4af68a37e
De’Ath, Russell W.
a047a00a-efa1-4892-8367-3637311d3055
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Threlfall, Terence L.
dc1fe3b2-c0c1-465c-942f-dbd4af68a37e
De’Ath, Russell W.
a047a00a-efa1-4892-8367-3637311d3055
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8

Threlfall, Terence L., De’Ath, Russell W. and Coles, Simon J. (2013) Metastable zone widths, conformational multiplicity, and seeding. Organic Process Research & Development, 17 (3), 578-584. (doi:10.1021/op3003486).

Record type: Article

Abstract

The propensity for crystallisation of acetanilides and propionanilides was compared both by polythermal metastable zone width measurements and by isothermal induction time measurements. Although there were clear relationships between the metastable zone widths and the conformational multiplicity in some cases, they broke down for the chloroacylanilides. This failure could not be fully accounted for by the difference in the crystal structures of the chloro compounds. A surprising dependence of crystal size on seeding effectiveness could explain some of the crystallisation behaviour, particularly for the induction period measurements.

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More information

Published date: March 2013
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences

Identifiers

Local EPrints ID: 362490
URI: http://eprints.soton.ac.uk/id/eprint/362490
PURE UUID: ce0facbd-8755-4ef0-ae8b-f86fa4fee301
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

Catalogue record

Date deposited: 25 Feb 2014 14:17
Last modified: 18 Feb 2021 16:53

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