Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups
Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups
A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.
5818-5825
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina S.
4d6d97df-dc13-4198-ac78-c8d5d80f77bf
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
28 October 2013
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina S.
4d6d97df-dc13-4198-ac78-c8d5d80f77bf
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Amin, Jahangir, Chuckowree, Irina S., Wang, Minghua, Tizzard, Graham J., Coles, Simon J. and Spencer, John
(2013)
Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups.
Organometallics, 32 (20), .
(doi:10.1021/om400359m).
Abstract
A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.
This record has no associated files available for download.
More information
Published date: 28 October 2013
Organisations:
Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences
Identifiers
Local EPrints ID: 362503
URI: http://eprints.soton.ac.uk/id/eprint/362503
ISSN: 0276-7333
PURE UUID: 23d3275b-b807-44f1-b163-f9327195ed22
Catalogue record
Date deposited: 26 Feb 2014 11:37
Last modified: 15 Mar 2024 03:10
Export record
Altmetrics
Contributors
Author:
Jahangir Amin
Author:
Irina S. Chuckowree
Author:
Minghua Wang
Author:
John Spencer
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
