The University of Southampton
University of Southampton Institutional Repository

Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups

Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups
Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups
A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.
0276-7333
5818-5825
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina S.
4d6d97df-dc13-4198-ac78-c8d5d80f77bf
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Chuckowree, Irina S.
4d6d97df-dc13-4198-ac78-c8d5d80f77bf
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4

Amin, Jahangir, Chuckowree, Irina S., Wang, Minghua, Tizzard, Graham J., Coles, Simon J. and Spencer, John (2013) Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups. Organometallics, 32 (20), 5818-5825. (doi:10.1021/om400359m).

Record type: Article

Abstract

A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.

Full text not available from this repository.

More information

Published date: 28 October 2013
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences

Identifiers

Local EPrints ID: 362503
URI: https://eprints.soton.ac.uk/id/eprint/362503
ISSN: 0276-7333
PURE UUID: 23d3275b-b807-44f1-b163-f9327195ed22
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

Catalogue record

Date deposited: 26 Feb 2014 11:37
Last modified: 06 Jun 2018 12:54

Export record

Altmetrics

Contributors

Author: Jahangir Amin
Author: Irina S. Chuckowree
Author: Minghua Wang
Author: Simon J. Coles ORCID iD
Author: John Spencer

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×