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Reagent-free flow chemistry

Reagent-free flow chemistry
Reagent-free flow chemistry
A range of flow chemistries unified by the overlapping concepts of Reagentless Synthesis and Reactive Intermediate Trapping were developed. Thermochemically-promoted transformations for the generation and trapping of reactive intermediates, such as ketenes and N-acyliminium species, are reported. A particular emphasis was given to acquire kinetic data by means of in-situ spectroscopy techniques. Photochemistry is another ‘reagentless’ technique that is much less used in organic synthesis than might be expected from its capabilities. Flow chemistry provides a timely opportunity to develop ‘user friendly’ photochemical flow reactors and validate the equipment on selected photochemical reactions. Organometallic compounds impose particular challenges when handled in flow. Homogeneous or immobilised cobalt reagents were tested in combination with commercial flow equipment. Flow syntheses of selected piano stool iron complexes are also presented. Finally mixing properties of simple-shaped commercial flow mixers were assessed due to their critical role in commercial flow platforms. A mixing test was developed and compared against established procedures.
Bolien, David
5714a236-3f98-4069-9f96-a920c7a2966c
Bolien, David
5714a236-3f98-4069-9f96-a920c7a2966c
Whitby, Richard
45632236-ab00-4ad0-a02d-6209043e818b

Bolien, David (2014) Reagent-free flow chemistry. University of Southampton, Chemistry, Doctoral Thesis, 215pp.

Record type: Thesis (Doctoral)

Abstract

A range of flow chemistries unified by the overlapping concepts of Reagentless Synthesis and Reactive Intermediate Trapping were developed. Thermochemically-promoted transformations for the generation and trapping of reactive intermediates, such as ketenes and N-acyliminium species, are reported. A particular emphasis was given to acquire kinetic data by means of in-situ spectroscopy techniques. Photochemistry is another ‘reagentless’ technique that is much less used in organic synthesis than might be expected from its capabilities. Flow chemistry provides a timely opportunity to develop ‘user friendly’ photochemical flow reactors and validate the equipment on selected photochemical reactions. Organometallic compounds impose particular challenges when handled in flow. Homogeneous or immobilised cobalt reagents were tested in combination with commercial flow equipment. Flow syntheses of selected piano stool iron complexes are also presented. Finally mixing properties of simple-shaped commercial flow mixers were assessed due to their critical role in commercial flow platforms. A mixing test was developed and compared against established procedures.

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Published date: 28 February 2014
Organisations: University of Southampton, Chemistry

Identifiers

Local EPrints ID: 362746
URI: http://eprints.soton.ac.uk/id/eprint/362746
PURE UUID: 92b73228-53a3-41b0-9572-7df3e7efe6cf
ORCID for Richard Whitby: ORCID iD orcid.org/0000-0002-9891-5502

Catalogue record

Date deposited: 17 Mar 2014 11:52
Last modified: 06 Jun 2018 13:19

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