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Increased regional deformation of the left ventricle in normal children with increased body mass index: implications for future cardiovascular health

Increased regional deformation of the left ventricle in normal children with increased body mass index: implications for future cardiovascular health
Increased regional deformation of the left ventricle in normal children with increased body mass index: implications for future cardiovascular health
The prevalence of obesity continues to increase in the developing world. The effects of obesity on the cardiovascular system include changes in systolic and diastolic function. More recently obesity has been linked with impairment of longitudinal myocardial deformation properties in children. We sought to determine the effect of increased body mass index (BMI) on cardiac deformation in a group of children taking part in the population-based Southampton Women’s Survey to detect early cardiovascular changes associated with increasing BMI before established obesity. Sixty-eight children at a mean age of 9.4 years old underwent assessment of longitudinal myocardial deformation in the basal septal segment of the left ventricle (LV) using two-dimensional speckle tracking echocardiography. Parameters of afterload and preload, which may influence deformation, were determined from cardiac magnetic resonance imaging. BMI was determined from the child’s height and weight at the time of echocardiogram. Greater pediatric BMI was associated with greater longitudinal myocardial deformation or strain in the basal septal segment of the LV (? = 1.6, p < 0.001); however, this was not related to contractility or strain rate in this part of the heart (? = 0.001, p = 0.92). The end-diastolic volume of the LV increased with increasing BMI (? = 3.93, p < 0.01). In young children, regional deformation in the LV increases with increasing BMI, whilst normal contractility is maintained. This effect may be explained by the increased preload of the LV associated with increased somatic growth. The long-term implications of this altered physiology need to be followed-up
0172-0643
315-322
Black, D.
6b0c944d-4ac9-4460-b80b-2c160b9a272c
Bryant, J.
508f497c-8b5a-468f-a37d-be9c26e4e49d
Peebles, C.
8eb51995-0f07-46f7-9ca2-f97301fefc3d
Davies, L.
62b6dfd3-69cd-4f3d-9527-a5c70c7c74a8
Inskip, H.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Vettukattil, Joseph J.
6733316f-b576-4864-b41f-5da015f78887
Hanson, M.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Black, D.
6b0c944d-4ac9-4460-b80b-2c160b9a272c
Bryant, J.
508f497c-8b5a-468f-a37d-be9c26e4e49d
Peebles, C.
8eb51995-0f07-46f7-9ca2-f97301fefc3d
Davies, L.
62b6dfd3-69cd-4f3d-9527-a5c70c7c74a8
Inskip, H.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Vettukattil, Joseph J.
6733316f-b576-4864-b41f-5da015f78887
Hanson, M.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Black, D., Bryant, J., Peebles, C., Davies, L., Inskip, H., Godfrey, K., Vettukattil, Joseph J. and Hanson, M. (2014) Increased regional deformation of the left ventricle in normal children with increased body mass index: implications for future cardiovascular health. Pediatric Cardiology, 35 (2), 315-322. (doi:10.1007/s00246-013-0778-1.). (PMID:23989614)

Record type: Article

Abstract

The prevalence of obesity continues to increase in the developing world. The effects of obesity on the cardiovascular system include changes in systolic and diastolic function. More recently obesity has been linked with impairment of longitudinal myocardial deformation properties in children. We sought to determine the effect of increased body mass index (BMI) on cardiac deformation in a group of children taking part in the population-based Southampton Women’s Survey to detect early cardiovascular changes associated with increasing BMI before established obesity. Sixty-eight children at a mean age of 9.4 years old underwent assessment of longitudinal myocardial deformation in the basal septal segment of the left ventricle (LV) using two-dimensional speckle tracking echocardiography. Parameters of afterload and preload, which may influence deformation, were determined from cardiac magnetic resonance imaging. BMI was determined from the child’s height and weight at the time of echocardiogram. Greater pediatric BMI was associated with greater longitudinal myocardial deformation or strain in the basal septal segment of the LV (? = 1.6, p < 0.001); however, this was not related to contractility or strain rate in this part of the heart (? = 0.001, p = 0.92). The end-diastolic volume of the LV increased with increasing BMI (? = 3.93, p < 0.01). In young children, regional deformation in the LV increases with increasing BMI, whilst normal contractility is maintained. This effect may be explained by the increased preload of the LV associated with increased somatic growth. The long-term implications of this altered physiology need to be followed-up

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Published date: February 2014
Organisations: Faculty of Medicine

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Local EPrints ID: 362759
URI: http://eprints.soton.ac.uk/id/eprint/362759
ISSN: 0172-0643
PURE UUID: 9c5ba9ba-9f21-4dfa-8870-b804cda355d7
ORCID for H. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for K. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for M. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 07 Mar 2014 11:24
Last modified: 07 Oct 2020 01:45

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Contributors

Author: D. Black
Author: J. Bryant
Author: C. Peebles
Author: L. Davies
Author: H. Inskip ORCID iD
Author: K. Godfrey ORCID iD
Author: Joseph J. Vettukattil
Author: M. Hanson ORCID iD

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