The University of Southampton
University of Southampton Institutional Repository

Life span extension by resveratrol, rapamycin, and metformin: the promise of dietary restriction mimetics for an healthy aging

Life span extension by resveratrol, rapamycin, and metformin: the promise of dietary restriction mimetics for an healthy aging
Life span extension by resveratrol, rapamycin, and metformin: the promise of dietary restriction mimetics for an healthy aging
Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age.
0951-6433
377-382
Mouchiroud, Laurent
4495bc23-51a4-4194-b632-a68e2e68d2ca
Molin, Laurent
d5b2179d-0dec-4b92-8ee0-75efa8e5760c
Dallière, Nicolas
fbefe788-fe69-48fe-8b07-efe4e78b9161
Solari, Florence
8bd42861-08ee-488a-82b9-6d0f363da4aa
Mouchiroud, Laurent
4495bc23-51a4-4194-b632-a68e2e68d2ca
Molin, Laurent
d5b2179d-0dec-4b92-8ee0-75efa8e5760c
Dallière, Nicolas
fbefe788-fe69-48fe-8b07-efe4e78b9161
Solari, Florence
8bd42861-08ee-488a-82b9-6d0f363da4aa

Mouchiroud, Laurent, Molin, Laurent, Dallière, Nicolas and Solari, Florence (2010) Life span extension by resveratrol, rapamycin, and metformin: the promise of dietary restriction mimetics for an healthy aging. Biofactors, 36 (5), 377-382. (doi:10.1002/biof.127). (PMID:20848587)

Record type: Article

Abstract

Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age.

Full text not available from this repository.

More information

Published date: September 2010
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 362879
URI: http://eprints.soton.ac.uk/id/eprint/362879
ISSN: 0951-6433
PURE UUID: 1b803815-0f97-4dc3-94c9-53612125ab98

Catalogue record

Date deposited: 13 Mar 2014 12:47
Last modified: 16 Jul 2019 21:10

Export record

Altmetrics

Contributors

Author: Laurent Mouchiroud
Author: Laurent Molin
Author: Nicolas Dallière
Author: Florence Solari

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×