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Prenatal and childhood growth, and hospitalization for alcohol use disorders in adulthood: the Helsinki birth cohort study

Prenatal and childhood growth, and hospitalization for alcohol use disorders in adulthood: the Helsinki birth cohort study
Prenatal and childhood growth, and hospitalization for alcohol use disorders in adulthood: the Helsinki birth cohort study
Background: small birth size - an indicator of a sub-optimal prenatal environment - and variation in growth after birth have been associated with non-communicable diseases in later life. We tested whether birth size or growth in childhood associated with the risk of hospital admission for alcohol use disorders (AUDs) from early to late adulthood.

Methods: the sample comprised 6544 men and 6050 women born between 1934 and 1944 in Helsinki, Finland. Data on anthropometric measures were extracted from medical records and diagnoses of AUD from the Finnish Hospital Discharge Register and Causes of Death Register covering a 40-year period from 1969 to 2008.

Results: altogether 171 women (2.8%) and 657 men (10.0%) were diagnosed at a hospital with AUD. After adjusting for major confounders, shorter length at birth, shorter height up to two years of age, and lower weight at two years associated with hospitalization for AUD in women. In men, slower growth in height, particularly from 2 to 7 years, and slower weight gain from 7 to 11 years as well as shorter height and lower weight at 7 and 11 years associated with a diagnosis of AUD in men.

Conclusions: pre- and postnatal growth associates with the risk for AUD later in life differently in women than in men: the fetal period and infancy seem to be the sensitive periods for women, whereas those for men the occur from toddlerhood onwards
1932-6203
e87404
Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Lahti, M.
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Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Kajantie, E.
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Forsen, T.
009ce53c-8bbf-4c5c-a21f-0bbdd1f999c4
Wahlbeck, K.
80c3bbb7-d95a-42d3-baf1-3ea728ae68b1
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
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Eriksson, J.G.
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Raikkonen, K.
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Lahti, J.
522c081a-8ed6-476a-b421-f07e9c498ecb
Lahti, M.
e03f7633-de06-4679-b6d1-58919cf06e80
Pesonen, A.K.
edd22dbe-e07d-4212-a476-aaff63f619f5
Heinonen, K.
667793ce-59c1-43d0-9f53-4f7790a9ed94
Kajantie, E.
d4e32f85-9988-4b83-b353-012210ea0151
Forsen, T.
009ce53c-8bbf-4c5c-a21f-0bbdd1f999c4
Wahlbeck, K.
80c3bbb7-d95a-42d3-baf1-3ea728ae68b1
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Eriksson, J.G.
eda300d2-b247-479f-95b9-f12d2c72e92b
Raikkonen, K.
926aba17-06cd-417b-b20f-ae400a2596a6

Lahti, J., Lahti, M., Pesonen, A.K., Heinonen, K., Kajantie, E., Forsen, T., Wahlbeck, K., Osmond, C., Barker, D.J., Eriksson, J.G. and Raikkonen, K. (2014) Prenatal and childhood growth, and hospitalization for alcohol use disorders in adulthood: the Helsinki birth cohort study. PLoS ONE, 9 (1), e87404. (doi:10.1371/journal.pone.0087404.). (PMID:24489908)

Record type: Article

Abstract

Background: small birth size - an indicator of a sub-optimal prenatal environment - and variation in growth after birth have been associated with non-communicable diseases in later life. We tested whether birth size or growth in childhood associated with the risk of hospital admission for alcohol use disorders (AUDs) from early to late adulthood.

Methods: the sample comprised 6544 men and 6050 women born between 1934 and 1944 in Helsinki, Finland. Data on anthropometric measures were extracted from medical records and diagnoses of AUD from the Finnish Hospital Discharge Register and Causes of Death Register covering a 40-year period from 1969 to 2008.

Results: altogether 171 women (2.8%) and 657 men (10.0%) were diagnosed at a hospital with AUD. After adjusting for major confounders, shorter length at birth, shorter height up to two years of age, and lower weight at two years associated with hospitalization for AUD in women. In men, slower growth in height, particularly from 2 to 7 years, and slower weight gain from 7 to 11 years as well as shorter height and lower weight at 7 and 11 years associated with a diagnosis of AUD in men.

Conclusions: pre- and postnatal growth associates with the risk for AUD later in life differently in women than in men: the fetal period and infancy seem to be the sensitive periods for women, whereas those for men the occur from toddlerhood onwards

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Published date: 29 January 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 362927
URI: http://eprints.soton.ac.uk/id/eprint/362927
ISSN: 1932-6203
PURE UUID: 9cfa8d50-610d-49a4-9585-7df7e85b40e7
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 14 Mar 2014 16:23
Last modified: 18 Feb 2021 16:45

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Contributors

Author: J. Lahti
Author: M. Lahti
Author: A.K. Pesonen
Author: K. Heinonen
Author: E. Kajantie
Author: T. Forsen
Author: K. Wahlbeck
Author: C. Osmond ORCID iD
Author: D.J. Barker
Author: J.G. Eriksson
Author: K. Raikkonen

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