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The tammar wallaby major histocompatibility complex shows evidence of past genomic instability

The tammar wallaby major histocompatibility complex shows evidence of past genomic instability
The tammar wallaby major histocompatibility complex shows evidence of past genomic instability
The wallaby MHC has been extensively remodeled since the American and Australian marsupials last shared a common ancestor. The instability is characterized by the movement of antigen presenting genes away from the core MHC, most likely via the presence and activity of retroviral elements. We propose that the movement of class II genes away from the ancestral class II region has allowed this gene family to expand and diversify in the wallaby. The duplication of TAP genes in the wallaby MHC makes this species a unique model organism for studying the relationship between MHC gene organization and function.
1471-2164
1-15
Siddle, Hannah V.
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Deakin, Janine E.
bb2933f3-143b-4cc2-9ab9-0863ef871f62
Coggill, Penny
dcc6d390-e2c2-4ad9-912b-193e5a22fcf7
Whilming, Laurens G.
ad43a678-07b1-4eeb-9c9b-c254045ac4c1
Harrow, Jennifer
0513d228-8548-4ed1-9716-5312c267384d
Kaufman, Jim
c2afcfb2-dc2b-45af-8c80-83ad341aa78f
Beck, Stephan
50f0c07a-19a8-4bca-adbc-af41a3800412
Belov, Katherine
53f3bf11-757e-466d-bc93-8958b7a9dae1
Siddle, Hannah V.
2f0c1307-55d3-4965-a8b0-495c4a799f27
Deakin, Janine E.
bb2933f3-143b-4cc2-9ab9-0863ef871f62
Coggill, Penny
dcc6d390-e2c2-4ad9-912b-193e5a22fcf7
Whilming, Laurens G.
ad43a678-07b1-4eeb-9c9b-c254045ac4c1
Harrow, Jennifer
0513d228-8548-4ed1-9716-5312c267384d
Kaufman, Jim
c2afcfb2-dc2b-45af-8c80-83ad341aa78f
Beck, Stephan
50f0c07a-19a8-4bca-adbc-af41a3800412
Belov, Katherine
53f3bf11-757e-466d-bc93-8958b7a9dae1

Siddle, Hannah V., Deakin, Janine E., Coggill, Penny, Whilming, Laurens G., Harrow, Jennifer, Kaufman, Jim, Beck, Stephan and Belov, Katherine (2011) The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics, 12, 1-15. (doi:10.1186/1471-2164-12-421). (PMID:21854592)

Record type: Article

Abstract

The wallaby MHC has been extensively remodeled since the American and Australian marsupials last shared a common ancestor. The instability is characterized by the movement of antigen presenting genes away from the core MHC, most likely via the presence and activity of retroviral elements. We propose that the movement of class II genes away from the ancestral class II region has allowed this gene family to expand and diversify in the wallaby. The duplication of TAP genes in the wallaby MHC makes this species a unique model organism for studying the relationship between MHC gene organization and function.

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Siddle et al. - 2011 - The tammar wallaby major histocompatibility complex shows evidence of past genomic instability.pdf - Version of Record
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Published date: August 2011
Organisations: Centre for Biological Sciences

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Local EPrints ID: 362973
URI: http://eprints.soton.ac.uk/id/eprint/362973
ISSN: 1471-2164
PURE UUID: ac15607d-2f8f-4ff6-b1f0-750b0b101d9e

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Date deposited: 18 Mar 2014 14:46
Last modified: 30 Jul 2019 18:46

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