MHC-linked and un-linked class I genes in the wallaby
MHC-linked and un-linked class I genes in the wallaby
We demonstrate that classical class I genes are not linked to antigen processing genes in the wallaby and provide evidence that retroviral elements were involved in their movement. The presence of retroviral elements most likely facilitated the formation of recombination hotspots and subsequent diversification of class I genes. The classical class I have moved away from antigen processing genes in eutherian mammals and the wallaby independently, but both lineages appear to have benefited from this loss of linkage by increasing the number of classical genes, perhaps enabling response to a wider range of pathogens. The discovery of non-classical orthologs between distantly related marsupial species is unusual for the rapidly evolving class I genes and may indicate an important marsupial specific function.
795-799
Siddle, Hannah V.
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Deakin, Janine E.
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Coggill, Penny
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Hart, Elizabeth
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Cheng, Yuanyuan
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Wong, Emily Sw
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Harrow, Jennifer
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Beck, Stephan
50f0c07a-19a8-4bca-adbc-af41a3800412
Belov, Katherine
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14 July 2009
Siddle, Hannah V.
2f0c1307-55d3-4965-a8b0-495c4a799f27
Deakin, Janine E.
bb2933f3-143b-4cc2-9ab9-0863ef871f62
Coggill, Penny
dcc6d390-e2c2-4ad9-912b-193e5a22fcf7
Hart, Elizabeth
bd6bd8ef-8a97-490f-894c-9e43aaaf1144
Cheng, Yuanyuan
5ecff653-5fa6-45f3-ae30-61d4e955f3ac
Wong, Emily Sw
ecacecb4-d879-48ee-ba9c-3028cc5895ea
Harrow, Jennifer
0513d228-8548-4ed1-9716-5312c267384d
Beck, Stephan
50f0c07a-19a8-4bca-adbc-af41a3800412
Belov, Katherine
53f3bf11-757e-466d-bc93-8958b7a9dae1
Siddle, Hannah V., Deakin, Janine E., Coggill, Penny, Hart, Elizabeth, Cheng, Yuanyuan, Wong, Emily Sw, Harrow, Jennifer, Beck, Stephan and Belov, Katherine
(2009)
MHC-linked and un-linked class I genes in the wallaby.
BMC Genomics, 10 (310), .
(doi:10.1186/1471-2164-10-310).
(PMID:19602235)
Abstract
We demonstrate that classical class I genes are not linked to antigen processing genes in the wallaby and provide evidence that retroviral elements were involved in their movement. The presence of retroviral elements most likely facilitated the formation of recombination hotspots and subsequent diversification of class I genes. The classical class I have moved away from antigen processing genes in eutherian mammals and the wallaby independently, but both lineages appear to have benefited from this loss of linkage by increasing the number of classical genes, perhaps enabling response to a wider range of pathogens. The discovery of non-classical orthologs between distantly related marsupial species is unusual for the rapidly evolving class I genes and may indicate an important marsupial specific function.
Text
Siddle et al. - 2009 - MHC-linked and un-linked class I genes in the wallaby(2).pdf
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Published date: 14 July 2009
Organisations:
Centre for Biological Sciences
Identifiers
Local EPrints ID: 362985
URI: http://eprints.soton.ac.uk/id/eprint/362985
ISSN: 1471-2164
PURE UUID: 7c348db7-08c1-4347-b747-fc757d870bb3
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Date deposited: 18 Mar 2014 16:30
Last modified: 15 Mar 2024 03:49
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Contributors
Author:
Janine E. Deakin
Author:
Penny Coggill
Author:
Elizabeth Hart
Author:
Yuanyuan Cheng
Author:
Emily Sw Wong
Author:
Jennifer Harrow
Author:
Stephan Beck
Author:
Katherine Belov
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