Pneumococcal serotype-specific antibodies persist through early childhood after infant immunization: follow-up from a randomized controlled trial
Pneumococcal serotype-specific antibodies persist through early childhood after infant immunization: follow-up from a randomized controlled trial
BACKGROUND: In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age. At 13 months of age, most of these children had pneumococcal serotype-specific IgG concentrations ?0.35 µg/ml and opsonophagocytic assay (OPA) titers ?8.
METHODS:Children who had participated in the original study were enrolled again at 3.5 years of age. Persistence of immunity following infant immunization with either PCV-7 or PCV-13 and the immune response to a PCV-13 booster at pre-school age were investigated.
RESULTS: In total, 108 children were followed-up to the age of 3.5 years and received a PCV-13 booster at this age. At least 76% of children who received PCV-7 or PCV-13 in infancy retained serotype-specific IgG concentrations ?0.35 µg/ml against each of 5/7 shared serotypes. For serotypes 4 and 18C, persistence was lower at 22-42%. At least 71% of PCV-13 group participants had IgG concentrations ?0.35 µg/ml against each of 4/6 of the additional PCV-13 serotypes; for serotypes 1 and 3 this proportion was 45% and 52%. In the PCV-7 group these percentages were significantly lower for serotypes 1, 5 and 7F. A pre-school PCV-13 booster was highly immunogenic and resulted in low rates of local and systemic adverse effects.
CONCLUSION: Despite some decline in antibody from 13 months of age, these data suggest that a majority of pre-school children maintain protective serotype-specific antibody concentrations following conjugate vaccination at 2, 4 and 12 months of age.
Truck, Johannes
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Snape, Matthew
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Tatangeli, Florencia
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Voysey, Merryn
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Yu, Ly-Mee
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Faust, S.N.
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Heath, Paul
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Finn, Adam
59ac74fa-55a6-448d-9e19-9dd2f4654d4b
Pollard, Andrew J.
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March 2014
Truck, Johannes
99a6a371-4159-4b9a-a3b3-3802adce788a
Snape, Matthew
132c3c2d-eda6-4ee0-b853-356b08aa6488
Tatangeli, Florencia
2098e09e-e985-42cd-a622-e9434affc7fe
Voysey, Merryn
fd433353-cd7b-41af-bc72-69781e8a0f81
Yu, Ly-Mee
ae5bebd5-e49c-4fb1-ada1-a7d669f8a87f
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Heath, Paul
5e8ea38e-9feb-4f6a-ad80-a93152be4c77
Finn, Adam
59ac74fa-55a6-448d-9e19-9dd2f4654d4b
Pollard, Andrew J.
f54083f3-c730-4ecb-937e-6fb11fdd6a21
Truck, Johannes, Snape, Matthew, Tatangeli, Florencia, Voysey, Merryn, Yu, Ly-Mee, Faust, S.N., Heath, Paul, Finn, Adam and Pollard, Andrew J.
(2014)
Pneumococcal serotype-specific antibodies persist through early childhood after infant immunization: follow-up from a randomized controlled trial.
PLoS ONE, 9 (3).
(doi:10.1371/journal.pone.0091413).
Abstract
BACKGROUND: In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age. At 13 months of age, most of these children had pneumococcal serotype-specific IgG concentrations ?0.35 µg/ml and opsonophagocytic assay (OPA) titers ?8.
METHODS:Children who had participated in the original study were enrolled again at 3.5 years of age. Persistence of immunity following infant immunization with either PCV-7 or PCV-13 and the immune response to a PCV-13 booster at pre-school age were investigated.
RESULTS: In total, 108 children were followed-up to the age of 3.5 years and received a PCV-13 booster at this age. At least 76% of children who received PCV-7 or PCV-13 in infancy retained serotype-specific IgG concentrations ?0.35 µg/ml against each of 5/7 shared serotypes. For serotypes 4 and 18C, persistence was lower at 22-42%. At least 71% of PCV-13 group participants had IgG concentrations ?0.35 µg/ml against each of 4/6 of the additional PCV-13 serotypes; for serotypes 1 and 3 this proportion was 45% and 52%. In the PCV-7 group these percentages were significantly lower for serotypes 1, 5 and 7F. A pre-school PCV-13 booster was highly immunogenic and resulted in low rates of local and systemic adverse effects.
CONCLUSION: Despite some decline in antibody from 13 months of age, these data suggest that a majority of pre-school children maintain protective serotype-specific antibody concentrations following conjugate vaccination at 2, 4 and 12 months of age.
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Published date: March 2014
Organisations:
Faculty of Medicine
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Local EPrints ID: 363262
URI: http://eprints.soton.ac.uk/id/eprint/363262
ISSN: 1932-6203
PURE UUID: 18060520-1ed0-4c82-a60e-bca828294c32
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Date deposited: 24 Mar 2014 11:12
Last modified: 15 Mar 2024 03:26
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Author:
Johannes Truck
Author:
Matthew Snape
Author:
Florencia Tatangeli
Author:
Merryn Voysey
Author:
Ly-Mee Yu
Author:
Paul Heath
Author:
Adam Finn
Author:
Andrew J. Pollard
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