The University of Southampton
University of Southampton Institutional Repository

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease
Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease
The expansion of the microglial population is one of the hallmarks of numerous brain disorders. The addition of circulating progenitors to the pool of brain macrophages can contribute to the progression of brain disease and needs to be precisely defined to better understand the evolution of the glial and inflammatory reactions in the brain. We have analyzed the degree of infiltration/recruitment of circulating monocytes to the microglial pool, in a prion disease model of chronic neurodegeneration. Our results indicate a minimal/absent level of CCR2-dependent recruitment of circulating monocytes, local proliferation of microglia is the main driving force maintaining the amplification of the population. A deficiency in CCR2, and thus the absence of recruitment of circulating monocytes, does not impact microglial dynamics, the inflammatory profile or the temporal behavioral course of prion disease. However, the lack of CCR2 has unexpected effects including the failure to recruit perivascular macrophages in diseased but not healthy CNS and a small reduction in microglia proliferation. These data define the composition of the CNS-resident macrophage populations in prion disease and will help to understand the dynamics of the CNS innate immune response during chronic neurodegeneration.
ME7 model, microglial proliferation, CCR2?/?, circulating monocytes, neurodegeneration
0894-1491
1041-1052
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Schetters, Sjoerd T.T.
6da38b4b-2f35-465c-bf3d-747e2ad80a1c
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Schetters, Sjoerd T.T.
6da38b4b-2f35-465c-bf3d-747e2ad80a1c
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4

Gomez-Nicola, Diego, Schetters, Sjoerd T.T. and Perry, V. Hugh (2014) Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease. Glia, 62 (7), 1041-1052. (doi:10.1002/glia.22660). (PMID:24648328)

Record type: Article

Abstract

The expansion of the microglial population is one of the hallmarks of numerous brain disorders. The addition of circulating progenitors to the pool of brain macrophages can contribute to the progression of brain disease and needs to be precisely defined to better understand the evolution of the glial and inflammatory reactions in the brain. We have analyzed the degree of infiltration/recruitment of circulating monocytes to the microglial pool, in a prion disease model of chronic neurodegeneration. Our results indicate a minimal/absent level of CCR2-dependent recruitment of circulating monocytes, local proliferation of microglia is the main driving force maintaining the amplification of the population. A deficiency in CCR2, and thus the absence of recruitment of circulating monocytes, does not impact microglial dynamics, the inflammatory profile or the temporal behavioral course of prion disease. However, the lack of CCR2 has unexpected effects including the failure to recruit perivascular macrophages in diseased but not healthy CNS and a small reduction in microglia proliferation. These data define the composition of the CNS-resident macrophage populations in prion disease and will help to understand the dynamics of the CNS innate immune response during chronic neurodegeneration.

PDF pdf.pdf - Version of Record
Available under License Other.
Download (1MB)

More information

Accepted/In Press date: 4 March 2014
e-pub ahead of print date: 19 March 2014
Published date: July 2014
Keywords: ME7 model, microglial proliferation, CCR2?/?, circulating monocytes, neurodegeneration
Organisations: Biomedicine

Identifiers

Local EPrints ID: 363378
URI: https://eprints.soton.ac.uk/id/eprint/363378
ISSN: 0894-1491
PURE UUID: cf1943bb-ed8c-49de-9470-2fc89006b10a
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 25 Mar 2014 11:06
Last modified: 06 Jun 2018 12:33

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×