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Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates

Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates
Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates
Objectives

To systematically review the literature pertaining to the prevalence of depression and anxiety in patients with prostate cancer as a function of treatment stage.

Design

Systematic review and meta-analysis.

Participants

4494 patients with prostate cancer from primary research investigations.

Primary outcome measure

The prevalence of clinical depression and anxiety in patients with prostate cancer as a function of treatment stage.

Results

We identified 27 full journal articles that met the inclusion criteria for entry into the meta-analysis resulting in a pooled sample size of 4494 patients. The meta-analysis of prevalence rates identified pretreatment, on-treatment and post-treatment depression prevalences of 17.27% (95% CI 15.06% to 19.72%), 14.70% (95% CI 11.92% to 17.99%) and 18.44% (95% CI 15.18% to 22.22%), respectively. Pretreatment, on-treatment and post-treatment anxiety prevalences were 27.04% (95% CI 24.26% to 30.01%), 15.09% (95% CI 12.15% to 18.60%) and 18.49% (95% CI 13.81% to 24.31%), respectively.

Conclusions

Our findings suggest that the prevalence of depression and anxiety in men with prostate cancer, across the treatment spectrum, is relatively high. In light of the growing emphasis placed on cancer survivorship, we consider that further research within this area is warranted to ensure that psychological distress in patients with prostate cancer is not underdiagnosed and undertreated.
mental health, statistics & research methods
e003901
Watts, S.
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Leydon, G.
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Birch, B.
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Prescott, P.
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Lai, Lily
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Eardley, S.
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Lewith, G.
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Watts, S.
a0590c6c-add8-4e03-8f20-b84743fbd83c
Leydon, G.
c5cdaff5-0fa1-4d38-b575-b97c2892ec40
Birch, B.
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Prescott, P.
c212465a-eecb-4997-acea-23cc8da93666
Lai, Lily
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Eardley, S.
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Lewith, G.
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Watts, S., Leydon, G., Birch, B., Prescott, P., Lai, Lily, Eardley, S. and Lewith, G. (2014) Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates. BMJ Open, 4 (3), e003901. (doi:10.1136/bmjopen-2013-003901). (PMID:24625637)

Record type: Article

Abstract

Objectives

To systematically review the literature pertaining to the prevalence of depression and anxiety in patients with prostate cancer as a function of treatment stage.

Design

Systematic review and meta-analysis.

Participants

4494 patients with prostate cancer from primary research investigations.

Primary outcome measure

The prevalence of clinical depression and anxiety in patients with prostate cancer as a function of treatment stage.

Results

We identified 27 full journal articles that met the inclusion criteria for entry into the meta-analysis resulting in a pooled sample size of 4494 patients. The meta-analysis of prevalence rates identified pretreatment, on-treatment and post-treatment depression prevalences of 17.27% (95% CI 15.06% to 19.72%), 14.70% (95% CI 11.92% to 17.99%) and 18.44% (95% CI 15.18% to 22.22%), respectively. Pretreatment, on-treatment and post-treatment anxiety prevalences were 27.04% (95% CI 24.26% to 30.01%), 15.09% (95% CI 12.15% to 18.60%) and 18.49% (95% CI 13.81% to 24.31%), respectively.

Conclusions

Our findings suggest that the prevalence of depression and anxiety in men with prostate cancer, across the treatment spectrum, is relatively high. In light of the growing emphasis placed on cancer survivorship, we consider that further research within this area is warranted to ensure that psychological distress in patients with prostate cancer is not underdiagnosed and undertreated.

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More information

e-pub ahead of print date: 13 March 2014
Published date: 13 March 2014
Keywords: mental health, statistics & research methods
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 363421
URI: https://eprints.soton.ac.uk/id/eprint/363421
PURE UUID: 404076ab-389d-4dd4-966c-66ec9d0f9e45
ORCID for G. Leydon: ORCID iD orcid.org/0000-0001-5986-3300

Catalogue record

Date deposited: 25 Mar 2014 10:39
Last modified: 15 Oct 2019 00:43

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