Integrated photonics for bioanalytical microsystems
Integrated photonics for bioanalytical microsystems
Microfabricated optical waveguides enable low-cost mass-production of compact, robust, bioanalysis chips, and are ideal for the integration of optical functions in microsystems. Fabrication techniques which revolutionised electronics are enabling a similar transformation in photonics, and optical circuits are particularly well suited to mass-produced bio/chemical sensor arrays exploiting surface chemistry, optical cell-sorters and for integration in microfluidic systems for advanced micro-cytometry. Highly sensitive and specific waveguide biosensors have been successfully demonstrated, and biosensors based on SPR and on fluorescence will be described. Recently, interest has grown in optical manipulation at surfaces as part of the toolbox of the "lab-on-a-chip" and advances in trapping and propulsion of biological cells in the evanescent fields of optical waveguides will be considered. In applications where the volume of a liquid or of a micron-scale object such as a biological cell is to be interrogated, non-evanescent in-plane optofluidic approaches must be adopted. A key component is the in-plane lens, which can be used for trapping, scattering, fluorescence or Raman measurements. Advances in technologies incorporating integrated lenses for microcytometry will be described.
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
June 2012
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Wilkinson, J.S.
(2012)
Integrated photonics for bioanalytical microsystems.
CIMTEC 2012, Montecatini-Terme, Italy.
09 - 13 Jun 2012.
Record type:
Conference or Workshop Item
(Other)
Abstract
Microfabricated optical waveguides enable low-cost mass-production of compact, robust, bioanalysis chips, and are ideal for the integration of optical functions in microsystems. Fabrication techniques which revolutionised electronics are enabling a similar transformation in photonics, and optical circuits are particularly well suited to mass-produced bio/chemical sensor arrays exploiting surface chemistry, optical cell-sorters and for integration in microfluidic systems for advanced micro-cytometry. Highly sensitive and specific waveguide biosensors have been successfully demonstrated, and biosensors based on SPR and on fluorescence will be described. Recently, interest has grown in optical manipulation at surfaces as part of the toolbox of the "lab-on-a-chip" and advances in trapping and propulsion of biological cells in the evanescent fields of optical waveguides will be considered. In applications where the volume of a liquid or of a micron-scale object such as a biological cell is to be interrogated, non-evanescent in-plane optofluidic approaches must be adopted. A key component is the in-plane lens, which can be used for trapping, scattering, fluorescence or Raman measurements. Advances in technologies incorporating integrated lenses for microcytometry will be described.
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Published date: June 2012
Venue - Dates:
CIMTEC 2012, Montecatini-Terme, Italy, 2012-06-09 - 2012-06-13
Organisations:
Optoelectronics Research Centre
Identifiers
Local EPrints ID: 363694
URI: http://eprints.soton.ac.uk/id/eprint/363694
PURE UUID: 662eb127-268f-4391-8776-03949de23652
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Date deposited: 31 Mar 2014 13:02
Last modified: 12 Dec 2021 02:32
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