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Monolayer detection of ion binding at a crown ether-functionalised supramolecular surface via an integrated optical Bragg grating

Monolayer detection of ion binding at a crown ether-functionalised supramolecular surface via an integrated optical Bragg grating
Monolayer detection of ion binding at a crown ether-functionalised supramolecular surface via an integrated optical Bragg grating
There have been significant recent developments in the field of integrated optical Bragg grating sensors for use in the biological domain, where changes in the thickness of a surface layer upon specific binding of biological targets allows quantitative detection. However in the chemical domain less work has been reported. We present here an integrated optical Bragg grating sensor, capable of evanescently detecting small changes in refractive index down to 10-6 RIU at infrared wavelengths, within a microfluidic system. The high spectral fidelity of the Bragg gratings combined with precise thermal compensation enables direct monitoring of the surface throughout the experiment. This allows the sensor to probe surface changes in situ and in real-time, from preparation through to chemical modification of the surface, so that the progress of dynamic surface-localized interactions can be followed. Here we describe confirmatory studies to validate this approach, including a comparison with the modelled optical system, before assessing the ability to detect binding of Group I cations at a crown ether-functionalised supramolecular surface. Unlike larger biological entities, for these small chemical species, simple additive changes in film-thickness no longer prevail.


There have been significant recent developments in the field of integrated optical Bragg grating sensors for use in the biological domain, where changes in the thickness of a surface layer upon specific binding of biological targets allows quantitative detection. However in the chemical domain less work has been reported. We present here an integrated optical Bragg grating sensor, capable of evanescently detecting small changes in refractive index down to 10-6 RIU at infrared wavelengths, within a microfluidic system. The high spectral fidelity of the Bragg gratings combined with precise thermal compensation enables direct monitoring of the surface throughout the experiment. This allows the sensor to probe surface changes in situ and in real-time, from preparation through to chemical modification of the surface, so that the progress of dynamic surface-localized interactions can be followed. Here we describe confirmatory studies to validate this approach, including a comparison with the modelled optical system, before assessing the ability to detect binding of Group I cations at a crown ether-functionalised supramolecular surface. Unlike larger biological entities, for these small chemical species, simple additive changes in film-thickness no longer prevail
0003-2654
2774-2782
Parker, Richard M.
b052ca4d-b6c7-4fdd-a2f9-45032f0ff13f
Wales, Dominic J.
c001ff27-d3ac-4d2e-859f-9e963fc0374c
Gates, James C.
b71e31a1-8caa-477e-8556-b64f6cae0dc2
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Smith, Peter G.R.
8979668a-8b7a-4838-9a74-1a7cfc6665f6
Grossel, Martin Christopher
403bf3ff-6364-44e9-ab46-52d84c6f0d56
Parker, Richard M.
b052ca4d-b6c7-4fdd-a2f9-45032f0ff13f
Wales, Dominic J.
c001ff27-d3ac-4d2e-859f-9e963fc0374c
Gates, James C.
b71e31a1-8caa-477e-8556-b64f6cae0dc2
Frey, Jeremy G.
ba60c559-c4af-44f1-87e6-ce69819bf23f
Smith, Peter G.R.
8979668a-8b7a-4838-9a74-1a7cfc6665f6
Grossel, Martin Christopher
403bf3ff-6364-44e9-ab46-52d84c6f0d56

Parker, Richard M., Wales, Dominic J., Gates, James C., Frey, Jeremy G., Smith, Peter G.R. and Grossel, Martin Christopher (2014) Monolayer detection of ion binding at a crown ether-functionalised supramolecular surface via an integrated optical Bragg grating. Analyst, 139, 2774-2782. (doi:10.1039/C4AN00283K).

Record type: Article

Abstract

There have been significant recent developments in the field of integrated optical Bragg grating sensors for use in the biological domain, where changes in the thickness of a surface layer upon specific binding of biological targets allows quantitative detection. However in the chemical domain less work has been reported. We present here an integrated optical Bragg grating sensor, capable of evanescently detecting small changes in refractive index down to 10-6 RIU at infrared wavelengths, within a microfluidic system. The high spectral fidelity of the Bragg gratings combined with precise thermal compensation enables direct monitoring of the surface throughout the experiment. This allows the sensor to probe surface changes in situ and in real-time, from preparation through to chemical modification of the surface, so that the progress of dynamic surface-localized interactions can be followed. Here we describe confirmatory studies to validate this approach, including a comparison with the modelled optical system, before assessing the ability to detect binding of Group I cations at a crown ether-functionalised supramolecular surface. Unlike larger biological entities, for these small chemical species, simple additive changes in film-thickness no longer prevail.


There have been significant recent developments in the field of integrated optical Bragg grating sensors for use in the biological domain, where changes in the thickness of a surface layer upon specific binding of biological targets allows quantitative detection. However in the chemical domain less work has been reported. We present here an integrated optical Bragg grating sensor, capable of evanescently detecting small changes in refractive index down to 10-6 RIU at infrared wavelengths, within a microfluidic system. The high spectral fidelity of the Bragg gratings combined with precise thermal compensation enables direct monitoring of the surface throughout the experiment. This allows the sensor to probe surface changes in situ and in real-time, from preparation through to chemical modification of the surface, so that the progress of dynamic surface-localized interactions can be followed. Here we describe confirmatory studies to validate this approach, including a comparison with the modelled optical system, before assessing the ability to detect binding of Group I cations at a crown ether-functionalised supramolecular surface. Unlike larger biological entities, for these small chemical species, simple additive changes in film-thickness no longer prevail

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More information

e-pub ahead of print date: 26 March 2014
Published date: 7 June 2014
Organisations: Optoelectronics Research Centre, Organic Chemistry: Synthesis, Catalysis and Flow, Computational Systems Chemistry

Identifiers

Local EPrints ID: 363737
URI: https://eprints.soton.ac.uk/id/eprint/363737
ISSN: 0003-2654
PURE UUID: bfd612ba-8226-49b5-a84e-9d42b9ce0632
ORCID for James C. Gates: ORCID iD orcid.org/0000-0001-8671-5987
ORCID for Jeremy G. Frey: ORCID iD orcid.org/0000-0003-0842-4302
ORCID for Peter G.R. Smith: ORCID iD orcid.org/0000-0003-0319-718X
ORCID for Martin Christopher Grossel: ORCID iD orcid.org/0000-0001-7469-6854

Catalogue record

Date deposited: 03 Apr 2014 08:23
Last modified: 17 Oct 2019 00:38

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