Pitted keratolysis: a clinical review

Abstract

Background:Pitted keratolysis is a bacterial infection that affects the plantar epidermis. Despite the condition being reported in many countries affecting both shod and unshod
populations, there is little guidance for clinicians providing evidence or best practice guidelines on the management of this often stubborn infection.

Methods:Using a structured search of a range of databases, papers were identified that reported treatments tested on patients with the condition.

Results:Most of the literature uncovered was generally of a low level, such as casebased reporting or small case series. Studies were focused mainly on the use of topical
antibiotic agents, such as clindamycin, erythromycin, fusidic acid, and mupirocin, often in combination with other measures, such as hygiene advice and the use of
antiperspirants. From the limited evidence available, the use of topical antibiotic agents shows some efficacy in the treatment of pitted keratolysis. However, there is currently no suggestion that oral antibiotic drug therapy alone is effective in managing the condition.

Conclusions:Currently, there is no consensus on the most effective approach to managing pitted keratolysis, but a combination of antimicrobial agents and adjunctive measures, such as antiperspirants, seems to demonstrate the most effective approach from the current literature available.

More information

Identifiers

Catalogue record

Export record

Altmetrics