Drug-DNA interaction protocols
Drug-DNA interaction protocols
The last few years have witnessed the creation of new generations of sequence reading compounds, which have incredible potential for targeting specific DNA sequences. In Drug-DNA Interaction Protocols, Second Edition, expert researchers explore these compounds, revealing how a deeper understanding of the structure of DNA, along with an improved ability to manipulate it, has led to much progress in recent years. Chapters describe a new arsenal of techniques for probing the interactions between drugs and DNA, including various biophysical techniques for quantifying these interactions and for describing them in molecular and atomic detail, and they comprehensively consider both molecular and cellular approaches. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.
biophysical techniques cellular approach, dna-ligand interactions, sequence reading compounds, sequence selectivity, structural approach
978-1-60327-417-3
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
2010
Fox, Keith R.
9da5debc-4e45-473e-ab8c-550d1104659f
Fox, Keith R.
(ed.)
(2010)
Drug-DNA interaction protocols
(Methods in Molecular Biology, 613),
New York, US.
Humana Press, 311pp.
Abstract
The last few years have witnessed the creation of new generations of sequence reading compounds, which have incredible potential for targeting specific DNA sequences. In Drug-DNA Interaction Protocols, Second Edition, expert researchers explore these compounds, revealing how a deeper understanding of the structure of DNA, along with an improved ability to manipulate it, has led to much progress in recent years. Chapters describe a new arsenal of techniques for probing the interactions between drugs and DNA, including various biophysical techniques for quantifying these interactions and for describing them in molecular and atomic detail, and they comprehensively consider both molecular and cellular approaches. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.
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Published date: 2010
Keywords:
biophysical techniques cellular approach, dna-ligand interactions, sequence reading compounds, sequence selectivity, structural approach
Organisations:
Centre for Biological Sciences
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Local EPrints ID: 364181
URI: http://eprints.soton.ac.uk/id/eprint/364181
ISBN: 978-1-60327-417-3
PURE UUID: 696d7482-2d62-464a-a873-80d3941f4d0c
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Date deposited: 08 Apr 2014 12:47
Last modified: 12 Dec 2021 02:36
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