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T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases

T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases
T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases
T cells, but not NK cells, are preferentially recruited to colorectal liver metastases. NK cells within colorectal metastases have an intrahepatic and potentially tolerogenic, rather than a peripheral, phenotype. Similar to primary tumours, the magnitude of the T cell infiltrate in colorectal metastases is positively associated with survival
1471-2407
180
Pugh, Siân A
83010563-0865-446c-ba71-95e2a45d9562
Harrison, Rebecca J.
848aa9dc-797f-40f8-b63d-bca0d90f7b55
Primrose, John N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Pugh, Siân A
83010563-0865-446c-ba71-95e2a45d9562
Harrison, Rebecca J.
848aa9dc-797f-40f8-b63d-bca0d90f7b55
Primrose, John N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Pugh, Siân A, Harrison, Rebecca J., Primrose, John N. and Khakoo, Salim I. (2014) T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases. BMC cancer, 14, 180. (doi:10.1186/1471-2407-14-180). (PMID:24625075)

Record type: Article

Abstract

T cells, but not NK cells, are preferentially recruited to colorectal liver metastases. NK cells within colorectal metastases have an intrahepatic and potentially tolerogenic, rather than a peripheral, phenotype. Similar to primary tumours, the magnitude of the T cell infiltrate in colorectal metastases is positively associated with survival

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Published date: 2014
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 364217
URI: http://eprints.soton.ac.uk/id/eprint/364217
ISSN: 1471-2407
PURE UUID: 15c56f64-7321-4b64-8b65-63ae20791007
ORCID for John N. Primrose: ORCID iD orcid.org/0000-0002-2069-7605
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 10 Apr 2014 08:54
Last modified: 15 Mar 2024 03:12

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Contributors

Author: Siân A Pugh
Author: Rebecca J. Harrison
Author: Salim I. Khakoo ORCID iD

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