Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.
Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.
Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.
e94915
Siervo, Mario
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Riley, Heather L.
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Fernandez, Bernadette O
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Leckstrom, Carl A.
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Martin, Daniel S.
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Mitchell, Kay
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Levett, Denny Z.H.
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Montgomery, Hugh E.
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Mythen, Monty G.
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Grocott, Michael P. W.
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Feelisch, Martin
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2014
Siervo, Mario
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Riley, Heather L.
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Fernandez, Bernadette O
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Leckstrom, Carl A.
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Martin, Daniel S.
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Mitchell, Kay
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Levett, Denny Z.H.
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Montgomery, Hugh E.
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Mythen, Monty G.
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Grocott, Michael P. W.
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Feelisch, Martin
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Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O, Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Grocott, Michael P. W. and Feelisch, Martin
(2014)
Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.
PLoS ONE, 9 (4), .
(doi:10.1371/journal.pone.0094915).
(PMID:15134560)
Abstract
Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.
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Published date: 2014
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 364357
URI: http://eprints.soton.ac.uk/id/eprint/364357
ISSN: 1932-6203
PURE UUID: f6d03e0a-0b56-40cd-a36b-53461709d7b0
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Date deposited: 24 Apr 2014 14:24
Last modified: 15 Mar 2024 04:02
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Author:
Mario Siervo
Author:
Heather L. Riley
Author:
Bernadette O Fernandez
Author:
Carl A. Leckstrom
Author:
Daniel S. Martin
Author:
Kay Mitchell
Author:
Denny Z.H. Levett
Author:
Hugh E. Montgomery
Author:
Monty G. Mythen
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