Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.


Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O, Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Grocott, Michael P. W. and Feelisch, Martin (2014) Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE, 9, (4), e94915. (doi:10.1371/journal.pone.0094915). (PMID:15134560).

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Description/Abstract

Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1371/journal.pone.0094915
ISSNs: 1932-6203 (print)
Subjects: R Medicine > RC Internal medicine
Organisations: Clinical & Experimental Sciences
ePrint ID: 364357
Date :
Date Event
2014Published
Date Deposited: 24 Apr 2014 14:24
Last Modified: 17 Apr 2017 13:55
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/364357

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