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Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.

Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.
Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.
Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.
1932-6203
e94915
Siervo, Mario
6e4aab41-a521-4bf6-8488-1ac48532de69
Riley, Heather L.
a2a22be0-1257-4ba5-af78-70753eefd388
Fernandez, Bernadette O
9890aabc-1fe6-4530-a51e-31182e537131
Leckstrom, Carl A.
f82761f1-4afd-4a33-8c3f-4078f6d8b26d
Martin, Daniel S.
f60d19f8-d4a0-44e2-b9b5-e6f18de00cd7
Mitchell, Kay
ab96393c-c922-4125-b3f8-2ad8a6e72289
Levett, Denny Z.H.
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Montgomery, Hugh E.
8082956e-3142-42b4-9f46-b0c9cee79785
Mythen, Monty G.
266ffcca-f8dd-49b4-abe4-0ffb035e2b35
Grocott, Michael P. W.
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Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Siervo, Mario
6e4aab41-a521-4bf6-8488-1ac48532de69
Riley, Heather L.
a2a22be0-1257-4ba5-af78-70753eefd388
Fernandez, Bernadette O
9890aabc-1fe6-4530-a51e-31182e537131
Leckstrom, Carl A.
f82761f1-4afd-4a33-8c3f-4078f6d8b26d
Martin, Daniel S.
f60d19f8-d4a0-44e2-b9b5-e6f18de00cd7
Mitchell, Kay
ab96393c-c922-4125-b3f8-2ad8a6e72289
Levett, Denny Z.H.
4b33b751-32be-4fa3-aaf7-b62e62f08de8
Montgomery, Hugh E.
8082956e-3142-42b4-9f46-b0c9cee79785
Mythen, Monty G.
266ffcca-f8dd-49b4-abe4-0ffb035e2b35
Grocott, Michael P. W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd

Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O, Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Grocott, Michael P. W. and Feelisch, Martin (2014) Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation. PLoS ONE, 9, (4), e94915. (doi:10.1371/journal.pone.0094915). (PMID:15134560).

Record type: Article

Abstract

Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.

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Published date: 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 364357
URI: http://eprints.soton.ac.uk/id/eprint/364357
ISSN: 1932-6203
PURE UUID: f6d03e0a-0b56-40cd-a36b-53461709d7b0
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 24 Apr 2014 14:24
Last modified: 18 Jul 2017 02:32

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Contributors

Author: Mario Siervo
Author: Heather L. Riley
Author: Bernadette O Fernandez
Author: Carl A. Leckstrom
Author: Daniel S. Martin
Author: Kay Mitchell
Author: Denny Z.H. Levett
Author: Hugh E. Montgomery
Author: Monty G. Mythen
Author: Martin Feelisch ORCID iD

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