Siervo, Mario, Riley, Heather L., Fernandez, Bernadette O, Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Grocott, Michael P. W. and Feelisch, Martin
Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.
PLoS ONE, 9, (4), . (doi:10.1371/journal.pone.0094915). (PMID:15134560).
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Sustained hypoxemia is associated with insulin resistance, whose magnitude correlates with the degree of oxidative stress and inflammation. The role of 4-HNE and IL-6 as key players in modifying the association between sustained hypoxia and insulin resistance merits further investigation.
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