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Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis

Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
Depression is common and a major cause of morbidity and mortality and is also known to have serious effects on quality of life. Both clinical and pharmacologic studies have implicated the role of brain-derived neurotrophic factor (BDNF) as a susceptibility locus for the development of mental illness, including depression, bipolar disorder, and schizophrenia. Population-based genetic studies have examined the association between BDNF and a variety of depression outcomes, but the results have not clearly established the role of BDNF in the development of this complex disorder. The aim of this study was to test for associations between two genetic variants in BDNF, Val66Met (rs6265) and -270 C > T, and depression measured in two independent samples. In this analysis we included 3,548 participants from British Women's Heart and Health Study (BWHHS) and 6,836 mothers from Avon Longitudinal Study of Parents and Children (ALSPAC) who had complete data on genotype and depression outcomes. We did not detect any strong evidence of associations between any of the two polymorphisms and indicators of depression in either BWHHS or ALSPAC samples. Further, we carried out a systematic review and meta-analysis of all association studies of these two BDNF polymorphisms and depression. The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression.
1552-4841
814-821
Chen, Lina
7c344d28-052d-41dd-a17a-acb383f13e05
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Lewis, Sarah J
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Yuan, Wei
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Abdollahi, Mohammad R.
96ec68db-6302-4216-9aaf-9951a44be8b8
Timpson, Nicholas J.
ef38d847-22ec-4030-99cb-e77986b0815d
Day, Ian N.M.
b749b30a-1f4c-40eb-af0e-a50427388b39
Ebrahim, Shah
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Smith, George Davey
f5bc8327-f2cb-49a0-8eae-4a6ba63207a2
Shugart, Yin Y.
df04db1d-db61-48d1-bbe0-09aad3ca8601
Chen, Lina
7c344d28-052d-41dd-a17a-acb383f13e05
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Lewis, Sarah J
ffd0c4a5-d8a0-46d8-a2b6-b5f611abee59
Yuan, Wei
934197a6-0708-4967-ab09-032f8327e4e5
Abdollahi, Mohammad R.
96ec68db-6302-4216-9aaf-9951a44be8b8
Timpson, Nicholas J.
ef38d847-22ec-4030-99cb-e77986b0815d
Day, Ian N.M.
b749b30a-1f4c-40eb-af0e-a50427388b39
Ebrahim, Shah
0f2ade5c-4ef6-4ca7-9f9b-9b60ba192b13
Smith, George Davey
f5bc8327-f2cb-49a0-8eae-4a6ba63207a2
Shugart, Yin Y.
df04db1d-db61-48d1-bbe0-09aad3ca8601

Chen, Lina, Lawlor, Debbie A., Lewis, Sarah J, Yuan, Wei, Abdollahi, Mohammad R., Timpson, Nicholas J., Day, Ian N.M., Ebrahim, Shah, Smith, George Davey and Shugart, Yin Y. (2008) Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B (6), 814-821. (doi:10.1002/ajmg.b.30686). (PMID:18205169)

Record type: Article

Abstract

Depression is common and a major cause of morbidity and mortality and is also known to have serious effects on quality of life. Both clinical and pharmacologic studies have implicated the role of brain-derived neurotrophic factor (BDNF) as a susceptibility locus for the development of mental illness, including depression, bipolar disorder, and schizophrenia. Population-based genetic studies have examined the association between BDNF and a variety of depression outcomes, but the results have not clearly established the role of BDNF in the development of this complex disorder. The aim of this study was to test for associations between two genetic variants in BDNF, Val66Met (rs6265) and -270 C > T, and depression measured in two independent samples. In this analysis we included 3,548 participants from British Women's Heart and Health Study (BWHHS) and 6,836 mothers from Avon Longitudinal Study of Parents and Children (ALSPAC) who had complete data on genotype and depression outcomes. We did not detect any strong evidence of associations between any of the two polymorphisms and indicators of depression in either BWHHS or ALSPAC samples. Further, we carried out a systematic review and meta-analysis of all association studies of these two BDNF polymorphisms and depression. The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression.

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Published date: 5 September 2008
Organisations: Cancer Sciences

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Local EPrints ID: 364366
URI: https://eprints.soton.ac.uk/id/eprint/364366
ISSN: 1552-4841
PURE UUID: 42f6b11d-1f8a-47e3-9550-0e2ec87e0acd

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Date deposited: 25 Apr 2014 13:28
Last modified: 25 Sep 2018 16:31

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Contributors

Author: Lina Chen
Author: Debbie A. Lawlor
Author: Sarah J Lewis
Author: Wei Yuan
Author: Nicholas J. Timpson
Author: Ian N.M. Day
Author: Shah Ebrahim
Author: George Davey Smith
Author: Yin Y. Shugart

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