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Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence

Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence
Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence
Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11-19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans.
1-7
Pike, Katharine C.
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Davis, Shelley A.
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Collins, Samuel A.
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Lucas, Jane S.A.
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Inskip, Hazel M.
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Wilson, Susan J.
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Thomas, Elin R.
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Wain, Harris A.
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Keskiväli-Bond, Piia H.M.
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Cooper, Cyrus
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Godfrey, Keith M.
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Torrens, Christopher
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Roberts, Graham
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Holloway, John W.
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Pike, Katharine C.
15d8a826-8acd-4c0a-836e-4b589336f449
Davis, Shelley A.
5759c22f-f581-4b2d-bafd-5d1207e48e84
Collins, Samuel A.
3c35238c-dbbd-4021-b7fa-c5b89e471981
Lucas, Jane S.A.
5cb3546c-87b2-4e59-af48-402076e25313
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Wilson, Susan J.
21c6875d-6870-441b-ae7a-603562a646b8
Thomas, Elin R.
52d3d8f1-3763-4583-b3c0-bf0a0b9f27cc
Wain, Harris A.
05e5170a-9a51-4386-bdf2-7bf78e8461ca
Keskiväli-Bond, Piia H.M.
200c631c-bde6-4634-bb11-dd18747f6154
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, Keith M.
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Torrens, Christopher
15a35713-0651-4249-8227-5901e2cfcd22
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a

Pike, Katharine C., Davis, Shelley A., Collins, Samuel A., Lucas, Jane S.A., Inskip, Hazel M., Wilson, Susan J., Thomas, Elin R., Wain, Harris A., Keskiväli-Bond, Piia H.M., Cooper, Cyrus, Godfrey, Keith M., Torrens, Christopher, Roberts, Graham and Holloway, John W. (2014) Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Scientific Reports, 4 (4705), 1-7. (doi:10.1038/srep04705). (PMID:24740086)

Record type: Article

Abstract

Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11-19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans.

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e-pub ahead of print date: 17 April 2014
Published date: 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 364450
URI: https://eprints.soton.ac.uk/id/eprint/364450
PURE UUID: 77447ccc-9e40-463a-8dd4-b98b4dd78aa3
ORCID for Hazel M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 29 Apr 2014 11:24
Last modified: 12 Nov 2019 02:02

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