Dushianthan, Ahilanandan, Goss, Victoria, Cusack, Rebecca, Grocott, Michael P.W. and Postle, Anthony D.
Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers
BMC Pulmonary Medicine, 14, . (doi:10.1186/1471-2466-14-10).
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Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states
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