Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers


Dushianthan, Ahilanandan, Goss, Victoria, Cusack, Rebecca, Grocott, Michael P.W. and Postle, Anthony D. (2014) Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers BMC Pulmonary Medicine, 14, p. 10. (doi:10.1186/1471-2466-14-10).

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Description/Abstract

Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states

Item Type: Article
Digital Object Identifier (DOI): doi:10.1186/1471-2466-14-10
ISSNs: 1471-2466 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine
Organisations: Clinical & Experimental Sciences
ePrint ID: 364477
Date :
Date Event
2014Published
Date Deposited: 01 May 2014 16:52
Last Modified: 23 Feb 2017 00:42
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/364477

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