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Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers

Dushianthan, Ahilanandan, Goss, Victoria, Cusack, Rebecca, Grocott, Michael P.W. and Postle, Anthony D. (2014) Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers BMC Pulmonary Medicine, 14, p. 10. (doi:10.1186/1471-2466-14-10).

Record type: Article


Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states

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Published date: 2014
Organisations: Clinical & Experimental Sciences


Local EPrints ID: 364477
ISSN: 1471-2466
PURE UUID: 363249b8-9a23-4233-b907-f1dc77aef4f8
ORCID for Anthony D. Postle: ORCID iD

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Date deposited: 01 May 2014 16:52
Last modified: 18 Jul 2017 02:31

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Author: Ahilanandan Dushianthan
Author: Victoria Goss
Author: Rebecca Cusack

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