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Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers

Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers
Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers
Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states
1471-2466
1-9
Dushianthan, Ahilanandan
013692a2-cf26-4278-80bd-9d8fcdb17751
Goss, Victoria
ef02be5d-9318-4f7d-b076-3153555980d0
Cusack, Rebecca
fbde153f-228e-456f-80b9-c0acbda4aeb2
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Dushianthan, Ahilanandan
013692a2-cf26-4278-80bd-9d8fcdb17751
Goss, Victoria
ef02be5d-9318-4f7d-b076-3153555980d0
Cusack, Rebecca
fbde153f-228e-456f-80b9-c0acbda4aeb2
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66

Dushianthan, Ahilanandan, Goss, Victoria, Cusack, Rebecca, Grocott, Michael P.W. and Postle, Anthony D. (2014) Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers. BMC Pulmonary Medicine, 14 (10), 1-9. (doi:10.1186/1471-2466-14-10).

Record type: Article

Abstract

Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states

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Published date: 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 364477
URI: https://eprints.soton.ac.uk/id/eprint/364477
ISSN: 1471-2466
PURE UUID: 363249b8-9a23-4233-b907-f1dc77aef4f8
ORCID for Ahilanandan Dushianthan: ORCID iD orcid.org/0000-0002-0165-3359
ORCID for Anthony D. Postle: ORCID iD orcid.org/0000-0001-7361-0756

Catalogue record

Date deposited: 01 May 2014 16:52
Last modified: 15 Aug 2019 00:58

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