Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers
Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers
Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states
1-9
Dushianthan, Ahilanandan
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Goss, Victoria
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Cusack, Rebecca
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Grocott, Michael P.W.
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Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
2014
Dushianthan, Ahilanandan
013692a2-cf26-4278-80bd-9d8fcdb17751
Goss, Victoria
ef02be5d-9318-4f7d-b076-3153555980d0
Cusack, Rebecca
dfb1595f-2792-4f76-ac6d-da027cf40146
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Dushianthan, Ahilanandan, Goss, Victoria, Cusack, Rebecca, Grocott, Michael P.W. and Postle, Anthony D.
(2014)
Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers.
BMC Pulmonary Medicine, 14 (10), .
(doi:10.1186/1471-2466-14-10).
Abstract
Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people. Despite minor differences, the phospholipid molecular composition of induced sputum also showed similarities to that of bronchoalveolar lavage fluid. Detailed analysis of newly synthesized individual phosphatidylcholine species provided novel insights into mechanisms of surfactant synthesis and acyl remodelling. Lysophosphatidylcholine methyl-D9 incorporation patterns suggest that these species are secreted together with other surfactant phospholipids and are not generated in the air spaces by hydrolysis of secreted surfactant phosphatidylcholine. Application into patient populations may elucidate potential underlying pathophysiological mechanisms that lead to surfactant alterations in disease states
Text
1471-2466-14-10.pdf
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Accepted/In Press date: 30 January 2014
e-pub ahead of print date: 1 February 2014
Published date: 2014
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 364477
URI: http://eprints.soton.ac.uk/id/eprint/364477
ISSN: 1471-2466
PURE UUID: 363249b8-9a23-4233-b907-f1dc77aef4f8
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Date deposited: 01 May 2014 16:52
Last modified: 15 Mar 2024 04:02
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Author:
Ahilanandan Dushianthan
Author:
Victoria Goss
Author:
Rebecca Cusack
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