Development of new fatty liver, or resolution of existing fatty liver, over five years of follow up, and risk of incident hypertension.
Development of new fatty liver, or resolution of existing fatty liver, over five years of follow up, and risk of incident hypertension.
Background & Aims
Approximately 50% of hypertensive patients have non-alcoholic fatty liver disease (NAFLD), but whether change in fatty liver status over time modifies risk of developing hypertension is uncertain. Our aim was to determine whether a change in fatty liver status (either development of new fatty liver, or resolution of existing fatty liver) over five years modified risk of incident hypertension at five year follow-up.
Methods
11,448 patients without hypertension were examined at baseline and at five year follow-up, using a retrospective cohort study design. Fatty liver status (absent or present) was assessed at baseline and follow-up using standard ultrasound criteria. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) for incident hypertension at follow-up were estimated controlling for potential confounders, compared to the reference group (patients who did not have fatty liver at either baseline or follow-up).
Results
911 patients developed incident hypertension. Incident fatty liver developed during follow-up in 1418 patients and fatty liver at baseline resolved during follow-up in 684 patients. Developing incident fatty liver was associated with incident hypertension, even after adjustment for multiple confounders (aOR = 1.60 (95% CI 1.30, 1.96; p <0.001). Further adjustment for change in body mass index between baseline and follow-up only slightly attenuated this association (aOR = 1.36 (95% CI 1.10, 1.67; p = 0.004). With resolution of fatty liver at follow-up, risk of incident hypertension was not different from the reference group (aOR = 1.21 (95% CI 0.90, 1.63; p = 0.21).
Conclusions
Development of incident fatty liver is associated with increased risk of hypertension.
1040-1045
Sung, K.C.
be77bd09-0bba-4fcf-8096-c0049ce4e2ce
Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
May 2014
Sung, K.C.
be77bd09-0bba-4fcf-8096-c0049ce4e2ce
Wild, S.H.
eb23a87e-b8da-4f3f-8dab-e02e7b5104aa
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Sung, K.C., Wild, S.H. and Byrne, Christopher D.
(2014)
Development of new fatty liver, or resolution of existing fatty liver, over five years of follow up, and risk of incident hypertension.
Journal of Hepatology, 60 (5), .
(doi:10.1016/j.jhep.2014.01.009).
(PMID:24445219)
Abstract
Background & Aims
Approximately 50% of hypertensive patients have non-alcoholic fatty liver disease (NAFLD), but whether change in fatty liver status over time modifies risk of developing hypertension is uncertain. Our aim was to determine whether a change in fatty liver status (either development of new fatty liver, or resolution of existing fatty liver) over five years modified risk of incident hypertension at five year follow-up.
Methods
11,448 patients without hypertension were examined at baseline and at five year follow-up, using a retrospective cohort study design. Fatty liver status (absent or present) was assessed at baseline and follow-up using standard ultrasound criteria. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) for incident hypertension at follow-up were estimated controlling for potential confounders, compared to the reference group (patients who did not have fatty liver at either baseline or follow-up).
Results
911 patients developed incident hypertension. Incident fatty liver developed during follow-up in 1418 patients and fatty liver at baseline resolved during follow-up in 684 patients. Developing incident fatty liver was associated with incident hypertension, even after adjustment for multiple confounders (aOR = 1.60 (95% CI 1.30, 1.96; p <0.001). Further adjustment for change in body mass index between baseline and follow-up only slightly attenuated this association (aOR = 1.36 (95% CI 1.10, 1.67; p = 0.004). With resolution of fatty liver at follow-up, risk of incident hypertension was not different from the reference group (aOR = 1.21 (95% CI 0.90, 1.63; p = 0.21).
Conclusions
Development of incident fatty liver is associated with increased risk of hypertension.
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More information
Accepted/In Press date: 6 January 2014
e-pub ahead of print date: 17 January 2014
Published date: May 2014
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 364588
URI: http://eprints.soton.ac.uk/id/eprint/364588
ISSN: 0168-8278
PURE UUID: 4640e75f-f903-4a9f-89f7-208aa6e19e25
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Date deposited: 02 May 2014 12:51
Last modified: 15 Mar 2024 03:02
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Contributors
Author:
K.C. Sung
Author:
S.H. Wild
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