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Asthma genetics and personalised medicine

Asthma genetics and personalised medicine
Asthma genetics and personalised medicine
Unbiased genetic approaches, especially genome-wide association studies, have identified novel genetic targets in the pathogenesis of asthma, but so far these targets account for only a small proportion of the heritability of asthma. Recognition of the importance of disease heterogeneity, the need for improved disease phenotyping, and the fact that genes involved in the inception of asthma are likely to be different from those involved in severity widens the scope of asthma genetics. The identification of genes implicated in several causal pathways suggests that genetic scores could be used to capture the effect of genetic variations on individuals. Gene–environment interaction adds another layer of complexity, which is being successfully explored by epigenetic approaches. Pharmacogenetics is one example of how gene–environment interactions are already being taken into account in the identification of drug responders and non-responders, and patients most susceptible to adverse effects. Such applications represent one component of personalised medicine, an approach that places the individual at the centre of health care
2213-2600
405-415
Meyers, Deborah A.
14376cf3-c6e8-4c56-ba99-24c4e9849771
Bleecker, Eugene R.
33edc1f3-57c5-44f6-93b7-311eea7e18ec
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Meyers, Deborah A.
14376cf3-c6e8-4c56-ba99-24c4e9849771
Bleecker, Eugene R.
33edc1f3-57c5-44f6-93b7-311eea7e18ec
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Meyers, Deborah A., Bleecker, Eugene R., Holloway, John W. and Holgate, Stephen T. (2014) Asthma genetics and personalised medicine. The Lancet Respiratory Medicine, 2 (5), 405-415. (doi:10.1016/S2213-2600(14)70012-8).

Record type: Article

Abstract

Unbiased genetic approaches, especially genome-wide association studies, have identified novel genetic targets in the pathogenesis of asthma, but so far these targets account for only a small proportion of the heritability of asthma. Recognition of the importance of disease heterogeneity, the need for improved disease phenotyping, and the fact that genes involved in the inception of asthma are likely to be different from those involved in severity widens the scope of asthma genetics. The identification of genes implicated in several causal pathways suggests that genetic scores could be used to capture the effect of genetic variations on individuals. Gene–environment interaction adds another layer of complexity, which is being successfully explored by epigenetic approaches. Pharmacogenetics is one example of how gene–environment interactions are already being taken into account in the identification of drug responders and non-responders, and patients most susceptible to adverse effects. Such applications represent one component of personalised medicine, an approach that places the individual at the centre of health care

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More information

Published date: 1 May 2014
Organisations: Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 364706
URI: https://eprints.soton.ac.uk/id/eprint/364706
ISSN: 2213-2600
PURE UUID: e479f03a-4d71-494e-9371-bb626a1f1392
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 09 May 2014 10:50
Last modified: 06 Jun 2018 12:59

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