Impact of lung surfactant on wettability and cytotoxicity of nanoparticles
Impact of lung surfactant on wettability and cytotoxicity of nanoparticles
The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge etc.). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles' dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely.
20573-20581
Ratoi, Monica
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Hoet, Peter H. M.
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Crossley, Alison
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Dobson, Peter
21096b17-d64b-4b42-a7d7-a08081ce730a
15 April 2014
Ratoi, Monica
cfeffe10-31ca-4630-8399-232c4bc2beff
Hoet, Peter H. M.
e0efa33f-e0c0-4f14-a60a-7b1cfc04757c
Crossley, Alison
7f9ec7c7-ea08-4138-97d0-872c82e4d9b4
Dobson, Peter
21096b17-d64b-4b42-a7d7-a08081ce730a
Ratoi, Monica, Hoet, Peter H. M., Crossley, Alison and Dobson, Peter
(2014)
Impact of lung surfactant on wettability and cytotoxicity of nanoparticles.
RSC Advances, 4 (39), .
(doi:10.1039/c3ra47374k).
Abstract
The importance of nanoparticle characterization for nanotoxicology has been extensively emphasized and it has been universally agreed that the most important parameters for characterizing nanomaterials are specific surface area and surface properties (chemistry, hydro-philicity/phobicity, charge etc.). This study is proposing the use of enthalpy of wetting which depends on both specific surface area and surface properties, is easily measurable and proves to be highly relevant for predicting nanoparticles' dispersion state and their interaction with the lungs. It also shows the conditioning effect of the lung surfactant main component, DPPC on the surface of particles when used in concentrations which mimic pulmonary exposure more closely.
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e-pub ahead of print date: 15 April 2014
Published date: 15 April 2014
Organisations:
nCATS Group
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Local EPrints ID: 364716
URI: http://eprints.soton.ac.uk/id/eprint/364716
ISSN: 2046-2069
PURE UUID: 5d89d302-53f9-4a8d-b519-914059512827
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Date deposited: 08 May 2014 09:17
Last modified: 15 Mar 2024 03:35
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Author:
Peter H. M. Hoet
Author:
Alison Crossley
Author:
Peter Dobson
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