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Risk factors for proliferative sickle retinopathy

Risk factors for proliferative sickle retinopathy
Risk factors for proliferative sickle retinopathy
The prevalence, incidence, and risk factors associated with proliferative sickle retinopathy (PSR) were investigated in 786 patients with homozygous sickle cell (SS) disease and 533 patients with sickle cell haemoglobin C (SC) disease. PSR was more common in SC disease, in which there was a significant predominance of males, and it increased with age in both genotypes. In SC disease the risk of developing PSR was highest between 15 and 24 years in males, between 20 and 39 years in females, and in SS disease between 25 and 39 years in both sexes. PSR tended to be bilateral, especially in SC disease. There was no evidence of familial clustering of PSR in SC siblings, and insufficient numbers of SS siblings were available to test for clustering. Haematological risk factors associated with PSR in SS disease were a high haemoglobin in males and a low fetal haemoglobin in both sexes and in SC disease, a high mean cell volume, and a low fetal haemoglobin in females
0007-1161
172-176
Fox, P.D.
44b69fce-cc5c-45c5-9660-7e3d3334799a
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, G.R.
0ee3a15b-b982-4b24-adbf-c1b0ebb65b71
Dunn, D.T.
b5c69c6f-2730-4dd1-a16c-312fdf300b17
Fox, P.D.
44b69fce-cc5c-45c5-9660-7e3d3334799a
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, G.R.
0ee3a15b-b982-4b24-adbf-c1b0ebb65b71
Dunn, D.T.
b5c69c6f-2730-4dd1-a16c-312fdf300b17

Fox, P.D., Morris, J.S., Serjeant, G.R. and Dunn, D.T. (1990) Risk factors for proliferative sickle retinopathy. British Journal of Ophthalmology, 74, 172-176. (doi:10.1136/bjo.74.3.172).

Record type: Article

Abstract

The prevalence, incidence, and risk factors associated with proliferative sickle retinopathy (PSR) were investigated in 786 patients with homozygous sickle cell (SS) disease and 533 patients with sickle cell haemoglobin C (SC) disease. PSR was more common in SC disease, in which there was a significant predominance of males, and it increased with age in both genotypes. In SC disease the risk of developing PSR was highest between 15 and 24 years in males, between 20 and 39 years in females, and in SS disease between 25 and 39 years in both sexes. PSR tended to be bilateral, especially in SC disease. There was no evidence of familial clustering of PSR in SC siblings, and insufficient numbers of SS siblings were available to test for clustering. Haematological risk factors associated with PSR in SS disease were a high haemoglobin in males and a low fetal haemoglobin in both sexes and in SC disease, a high mean cell volume, and a low fetal haemoglobin in females

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Published date: 1990
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365101
URI: https://eprints.soton.ac.uk/id/eprint/365101
ISSN: 0007-1161
PURE UUID: dcc68ad6-6b34-42e9-8483-5a8ab995975a

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Date deposited: 29 May 2014 10:27
Last modified: 18 Jul 2017 02:24

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