The red cell distribution width - is it of clinical value?
The red cell distribution width - is it of clinical value?
The red cell distribution width (RDW) has been studied during the clinical steady state in 1121 patients with homozygous sickle cell (SS) disease, 344 with sickle cell-haemoglobin C (SC) disease, 68 with sickle cell-beta+ thalassaemia, 49 with sickle cell beta 0 thalassaemia and in 130 control subjects with a normal (AA) genotype. The mean RDW was moderately increased in S beta + thalassaemia and SC disease and markedly increased in S beta 0 thalassaemia and SS disease. In SS, SC and S beta 0 thalassaemia genotypes, lower RDW values occurred in females and with alpha thalassaemia. The RDW correlated negatively with total haemoglobin, mean cell haemoglobin concentration, mean cell volume, and fetal haemoglobin (HbF) and positively with reticulocyte count in SS disease. A low RDW was associated with higher weight and less frequent dactylitis, painful crisis, acute chest syndrome, acute splenic sequestration, and hospital admissions. A low RDW in SS disease is consistent with a high total haemoglobin, high HbF, low reticulocyte count, alpha thalassaemia, and a more mild clinical course
229-237
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Grandison, Y.
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Mason, K.
150ce36a-14f3-4077-97b2-89af1cf037da
Thompson, M.
9678cbee-9f4e-4eba-97d7-a8f573ff4901
Higgs, D.
5ecf40f0-dec7-46c2-8bd8-84f5911706de
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, B.
6701f986-d030-4e32-abad-f55dbf027d1b
Serjeant, G.
31cb7780-248d-4ec2-a4e6-602433dd514e
1991
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Grandison, Y.
c355e7c3-842c-428a-bdea-0e7d7124c91d
Mason, K.
150ce36a-14f3-4077-97b2-89af1cf037da
Thompson, M.
9678cbee-9f4e-4eba-97d7-a8f573ff4901
Higgs, D.
5ecf40f0-dec7-46c2-8bd8-84f5911706de
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, B.
6701f986-d030-4e32-abad-f55dbf027d1b
Serjeant, G.
31cb7780-248d-4ec2-a4e6-602433dd514e
Thame, M., Grandison, Y., Mason, K., Thompson, M., Higgs, D., Morris, J.S., Serjeant, B. and Serjeant, G.
(1991)
The red cell distribution width - is it of clinical value?
Clinical & Laboratory Haematology, 13 (3), .
(PMID:1794225)
Abstract
The red cell distribution width (RDW) has been studied during the clinical steady state in 1121 patients with homozygous sickle cell (SS) disease, 344 with sickle cell-haemoglobin C (SC) disease, 68 with sickle cell-beta+ thalassaemia, 49 with sickle cell beta 0 thalassaemia and in 130 control subjects with a normal (AA) genotype. The mean RDW was moderately increased in S beta + thalassaemia and SC disease and markedly increased in S beta 0 thalassaemia and SS disease. In SS, SC and S beta 0 thalassaemia genotypes, lower RDW values occurred in females and with alpha thalassaemia. The RDW correlated negatively with total haemoglobin, mean cell haemoglobin concentration, mean cell volume, and fetal haemoglobin (HbF) and positively with reticulocyte count in SS disease. A low RDW was associated with higher weight and less frequent dactylitis, painful crisis, acute chest syndrome, acute splenic sequestration, and hospital admissions. A low RDW in SS disease is consistent with a high total haemoglobin, high HbF, low reticulocyte count, alpha thalassaemia, and a more mild clinical course
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Published date: 1991
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 365114
URI: http://eprints.soton.ac.uk/id/eprint/365114
PURE UUID: 89039ac6-c508-482c-b1f8-9a3bbfe3e7a8
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Date deposited: 22 May 2014 11:28
Last modified: 11 Dec 2021 04:15
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Contributors
Author:
M. Thame
Author:
Y. Grandison
Author:
K. Mason
Author:
M. Thompson
Author:
D. Higgs
Author:
J.S. Morris
Author:
B. Serjeant
Author:
G. Serjeant
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