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Cohort study of HIV negative tuberculosis, Nairobi, Kenya: comparison of bacteriological results

Cohort study of HIV negative tuberculosis, Nairobi, Kenya: comparison of bacteriological results
Cohort study of HIV negative tuberculosis, Nairobi, Kenya: comparison of bacteriological results
We have set up a cohort of human immunodeficiency virus (HIV) positive and negative patients with tuberculosis in order to address the problems associated with HIV-related tuberculosis. We present here the results of sputum smear microscopy, culture, mycobacterial identification tests and drug susceptibility assays from specimens taken at presentation. In this selected population of largely pulmonary tuberculosis cases, HIV infection is not associated with significant differences in sputum smear positivity rate, culture positivity rate or initial drug resistance. No atypical mycobacteria were found. Direct sputum smear examination remains specific for the diagnosis of tuberculosis in Kenya in spite of the presence of HIV. HIV infection was not associated with an increase in the proportion of pulmonary cases still culture-positive at 6 months. However a significant increase in the proportion of cases still culture-positive at 6 months was seen in those with initially resistant strains and also in those treated with standard regimen (streptomycin, thiacetazone and isoniazid for 1 month followed by thiacetazone and isoniazid for 11 months, 1STH/11TH) rather than a short-course, rifampicin-containing regimen (rifampicin, pyrazinamide and isoniazid for 2 months, together with streptomycin for the first month and followed by 6 months of thiacetazone and isoniazid, SHRZ/6TH)
0962-8479
203-209
Githui, W.
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Nunn, P.
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Juma, E.
eb0f008f-6c56-497f-8653-2adcdde56d8d
Karimi, F.
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Brindle, R.
cfabdbbd-39c7-4b3f-8417-3090689b58eb
Kamunyi, R.
f9796cce-d7b6-4c14-8287-c00b17e1b69f
Gathua, S.
6a397cb4-6546-4c4a-b66a-c80a08929e54
Gicheha, C.
97b594d2-497e-4d9a-9405-0b2714193ed0
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Omwega, M.
c1a7bbab-e3be-45ac-9065-74bd3c162581
Githui, W.
9d78f21a-c8af-4952-98f0-14b630ef675b
Nunn, P.
2d7ddc4a-f5aa-4ef0-9c5e-5b7be3d4b8ef
Juma, E.
eb0f008f-6c56-497f-8653-2adcdde56d8d
Karimi, F.
4a92c333-3407-4d50-a9e6-997ca3f511e3
Brindle, R.
cfabdbbd-39c7-4b3f-8417-3090689b58eb
Kamunyi, R.
f9796cce-d7b6-4c14-8287-c00b17e1b69f
Gathua, S.
6a397cb4-6546-4c4a-b66a-c80a08929e54
Gicheha, C.
97b594d2-497e-4d9a-9405-0b2714193ed0
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Omwega, M.
c1a7bbab-e3be-45ac-9065-74bd3c162581

Githui, W., Nunn, P., Juma, E., Karimi, F., Brindle, R., Kamunyi, R., Gathua, S., Gicheha, C., Morris, J.S. and Omwega, M. (1992) Cohort study of HIV negative tuberculosis, Nairobi, Kenya: comparison of bacteriological results. Tubercle and Lung Disease, 73 (4), 203-209. (doi:10.1016/0962-8479(92)90087-Z). (PMID:1477386)

Record type: Article

Abstract

We have set up a cohort of human immunodeficiency virus (HIV) positive and negative patients with tuberculosis in order to address the problems associated with HIV-related tuberculosis. We present here the results of sputum smear microscopy, culture, mycobacterial identification tests and drug susceptibility assays from specimens taken at presentation. In this selected population of largely pulmonary tuberculosis cases, HIV infection is not associated with significant differences in sputum smear positivity rate, culture positivity rate or initial drug resistance. No atypical mycobacteria were found. Direct sputum smear examination remains specific for the diagnosis of tuberculosis in Kenya in spite of the presence of HIV. HIV infection was not associated with an increase in the proportion of pulmonary cases still culture-positive at 6 months. However a significant increase in the proportion of cases still culture-positive at 6 months was seen in those with initially resistant strains and also in those treated with standard regimen (streptomycin, thiacetazone and isoniazid for 1 month followed by thiacetazone and isoniazid for 11 months, 1STH/11TH) rather than a short-course, rifampicin-containing regimen (rifampicin, pyrazinamide and isoniazid for 2 months, together with streptomycin for the first month and followed by 6 months of thiacetazone and isoniazid, SHRZ/6TH)

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Published date: 1992
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365120
URI: https://eprints.soton.ac.uk/id/eprint/365120
ISSN: 0962-8479
PURE UUID: 7c3963e8-66de-4cd1-97c6-77ec41ba96fd

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Date deposited: 23 May 2014 12:19
Last modified: 18 Jul 2017 02:24

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Contributors

Author: W. Githui
Author: P. Nunn
Author: E. Juma
Author: F. Karimi
Author: R. Brindle
Author: R. Kamunyi
Author: S. Gathua
Author: C. Gicheha
Author: J.S. Morris
Author: M. Omwega

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