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Laser photocoagulastion for proliferative retinopathy in sickle haemoglobin C disease

Laser photocoagulastion for proliferative retinopathy in sickle haemoglobin C disease
Laser photocoagulastion for proliferative retinopathy in sickle haemoglobin C disease
The effect of sectoral, scatter laser photocoagulation on proliferative sickle retinopathy (PSR) was investigated by reviewing fluorescein angiograms of 88 sickle cell-haemoglobin C patients enrolled in a controlled, randomised trial. Follow-up was for a median period of 2.9 years. Complete infarction of all PSR in an eye occurred in 7 of 74 treated eyes and 2 of 60 control eyes. Treatment resulted in significantly greater regression (decrease in number or size of PSR lesions) in eyes of patients aged <25 years at enrolment but not in eyes of patients 25 years at enrolment. Infarction of individual PSR lesions was significantly more common in treated eyes. Treated PSR was significantly more likely to infarct if small (<15° circumferential involvement) and if flat rather than elevated. New PSR was significantly less likely to develop in treated eyes
laser photocoagulation, proliferative retinopathy, sickle cell disease
0950-222X
703-706
Fox, P.D.
44b69fce-cc5c-45c5-9660-7e3d3334799a
Minniger, K.
f2aeaf64-2cb1-46dd-9bb4-909673011660
Forshaw, M.L.
448b4172-7ca3-4a5e-8b6e-54d7eb959931
Vessey, S.J.
fd761fb8-d650-4332-960c-6d622898b2b0
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, G.R.
0ee3a15b-b982-4b24-adbf-c1b0ebb65b71
Fox, P.D.
44b69fce-cc5c-45c5-9660-7e3d3334799a
Minniger, K.
f2aeaf64-2cb1-46dd-9bb4-909673011660
Forshaw, M.L.
448b4172-7ca3-4a5e-8b6e-54d7eb959931
Vessey, S.J.
fd761fb8-d650-4332-960c-6d622898b2b0
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, G.R.
0ee3a15b-b982-4b24-adbf-c1b0ebb65b71

Fox, P.D., Minniger, K., Forshaw, M.L., Vessey, S.J., Morris, J.S. and Serjeant, G.R. (1993) Laser photocoagulastion for proliferative retinopathy in sickle haemoglobin C disease. Eye, 7, 703-706. (doi:10.1038/eye.1993.160). (PMID:8287998)

Record type: Article

Abstract

The effect of sectoral, scatter laser photocoagulation on proliferative sickle retinopathy (PSR) was investigated by reviewing fluorescein angiograms of 88 sickle cell-haemoglobin C patients enrolled in a controlled, randomised trial. Follow-up was for a median period of 2.9 years. Complete infarction of all PSR in an eye occurred in 7 of 74 treated eyes and 2 of 60 control eyes. Treatment resulted in significantly greater regression (decrease in number or size of PSR lesions) in eyes of patients aged <25 years at enrolment but not in eyes of patients 25 years at enrolment. Infarction of individual PSR lesions was significantly more common in treated eyes. Treated PSR was significantly more likely to infarct if small (<15° circumferential involvement) and if flat rather than elevated. New PSR was significantly less likely to develop in treated eyes

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Published date: 1993
Keywords: laser photocoagulation, proliferative retinopathy, sickle cell disease
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365123
URI: https://eprints.soton.ac.uk/id/eprint/365123
ISSN: 0950-222X
PURE UUID: 1f80f82d-26f8-4587-9d2f-9cf641bf642d

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Date deposited: 23 May 2014 12:57
Last modified: 18 Jul 2017 02:24

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Contributors

Author: P.D. Fox
Author: K. Minniger
Author: M.L. Forshaw
Author: S.J. Vessey
Author: J.S. Morris
Author: G.R. Serjeant

University divisions

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