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HIV-2-infected patients survive longer than HIV-1-infected patients

HIV-2-infected patients survive longer than HIV-1-infected patients
HIV-2-infected patients survive longer than HIV-1-infected patients
Objective: to compare survival of patients infected with HIV-1 and HIV-2.

Design: longitudinal follow-up of 175 HIV-1-and 294 HIV-2-infected patients identified in, or referred to a hospital in The Gambia.

Methods: survival analysis methods were used and the death rate ratios for HIV-2 relative to HIV-1 patients were estimated using proportional hazard regression models that allowed for age, sex and clinical or immunological features.

Results: the overall death rate ratio for HIV-2 relative to HIV-1 was 0.67 [95% confidence interval (Cl), 0.49-0.91] when adjusted for age, sex and World Health Organization Bangui clinical classification. When allowing for age, sex and three strata of CD4+ count, the rate ratio was 0.64 (95% Cl, 0.43-0.94), and for three strata of [beta]2-microglobulin levels 0.60 (95% Cl, 0.42-0.84).

Conclusion: mortality rate in HIV-2-infected patients is approximately two-thirds of that for HIV-1-infected patients
1617-1620
Whittle, H.
aae12997-cc35-4ec7-933b-5afceedd926c
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Todd, J.
8d0d2b35-64af-4912-a34f-01cd6b174eb2
Corrah, T.
2453b490-0dfd-4e97-88d2-7812d6513e9e
Sabally, S.
a16ebe38-95cc-4a74-b956-82f5e113c86e
Bangali, J.
d73a44bd-21ba-4fd3-b2b5-469f68616aef
Ngom, P.T.
e90352d0-5b7d-4fb9-adef-0dc84bec099e
Rolfe, M.
5cf21243-5503-47c6-8a5e-d1c03e1f17a3
Wilkins, Adrian
71b5c44a-cbbd-4a42-bdff-dd7775970561
Whittle, H.
aae12997-cc35-4ec7-933b-5afceedd926c
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Todd, J.
8d0d2b35-64af-4912-a34f-01cd6b174eb2
Corrah, T.
2453b490-0dfd-4e97-88d2-7812d6513e9e
Sabally, S.
a16ebe38-95cc-4a74-b956-82f5e113c86e
Bangali, J.
d73a44bd-21ba-4fd3-b2b5-469f68616aef
Ngom, P.T.
e90352d0-5b7d-4fb9-adef-0dc84bec099e
Rolfe, M.
5cf21243-5503-47c6-8a5e-d1c03e1f17a3
Wilkins, Adrian
71b5c44a-cbbd-4a42-bdff-dd7775970561

Whittle, H., Morris, J.S., Todd, J., Corrah, T., Sabally, S., Bangali, J., Ngom, P.T., Rolfe, M. and Wilkins, Adrian (1994) HIV-2-infected patients survive longer than HIV-1-infected patients. AIDS, 8 (11), 1617-1620. (PMID:7848600)

Record type: Article

Abstract

Objective: to compare survival of patients infected with HIV-1 and HIV-2.

Design: longitudinal follow-up of 175 HIV-1-and 294 HIV-2-infected patients identified in, or referred to a hospital in The Gambia.

Methods: survival analysis methods were used and the death rate ratios for HIV-2 relative to HIV-1 patients were estimated using proportional hazard regression models that allowed for age, sex and clinical or immunological features.

Results: the overall death rate ratio for HIV-2 relative to HIV-1 was 0.67 [95% confidence interval (Cl), 0.49-0.91] when adjusted for age, sex and World Health Organization Bangui clinical classification. When allowing for age, sex and three strata of CD4+ count, the rate ratio was 0.64 (95% Cl, 0.43-0.94), and for three strata of [beta]2-microglobulin levels 0.60 (95% Cl, 0.42-0.84).

Conclusion: mortality rate in HIV-2-infected patients is approximately two-thirds of that for HIV-1-infected patients

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Published date: 1994
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 365129
URI: https://eprints.soton.ac.uk/id/eprint/365129
PURE UUID: 8790303d-9a91-475f-a897-54e8c214d408

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Date deposited: 29 May 2014 12:45
Last modified: 18 Jul 2017 02:24

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Contributors

Author: H. Whittle
Author: J.S. Morris
Author: J. Todd
Author: T. Corrah
Author: S. Sabally
Author: J. Bangali
Author: P.T. Ngom
Author: M. Rolfe
Author: Adrian Wilkins

University divisions

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