HIV-2-infected patients survive longer than HIV-1-infected patients

Whittle, H., Morris, J.S., Todd, J., Corrah, T., Sabally, S., Bangali, J., Ngom, P.T., Rolfe, M. and Wilkins, Adrian (1994) HIV-2-infected patients survive longer than HIV-1-infected patients. AIDS, 8 (11), 1617-1620. (PMID:7848600)

Abstract

Objective: to compare survival of patients infected with HIV-1 and HIV-2.

Design: longitudinal follow-up of 175 HIV-1-and 294 HIV-2-infected patients identified in, or referred to a hospital in The Gambia.

Methods: survival analysis methods were used and the death rate ratios for HIV-2 relative to HIV-1 patients were estimated using proportional hazard regression models that allowed for age, sex and clinical or immunological features.

Results: the overall death rate ratio for HIV-2 relative to HIV-1 was 0.67 [95% confidence interval (Cl), 0.49-0.91] when adjusted for age, sex and World Health Organization Bangui clinical classification. When allowing for age, sex and three strata of CD4+ count, the rate ratio was 0.64 (95% Cl, 0.43-0.94), and for three strata of [beta]2-microglobulin levels 0.60 (95% Cl, 0.42-0.84).

Conclusion: mortality rate in HIV-2-infected patients is approximately two-thirds of that for HIV-1-infected patients

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